Circulating platelet-neutrophil aggregates characterize the development of type 1 diabetes in humans and NOD mice

Platelet-neutrophil aggregates (PNAs) facilitate neutrophil activation and migration and could underpin the recruitment of neutrophils to the pancreas during type 1 diabetes (T1D) pathogenesis. PNAs, measured by flow cytometry, were significantly elevated in the circulation of autoantibody-positive...

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Detalles Bibliográficos
Autores principales: Popp, Sarah K., Vecchio, Federica, Brown, Debra J., Fukuda, Riho, Suzuki, Yuri, Takeda, Yuma, Wakamatsu, Rikako, Sarma, Mahalakshmi A., Garrett, Jessica, Giovenzana, Anna, Bosi, Emanuele, Lafferty, Antony R.A., Brown, Karen J., Gardiner, Elizabeth E., Coupland, Lucy A., Thomas, Helen E., Chong, Beng H., Parish, Christopher R., Battaglia, Manuela, Petrelli, Alessandra, Simeonovic, Charmaine J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855805/
https://www.ncbi.nlm.nih.gov/pubmed/35076023
http://dx.doi.org/10.1172/jci.insight.153993

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