Ceramide-mediated gut dysbiosis enhances cholesterol esterification and promotes colorectal tumorigenesis in mice

Colorectal cancer (CRC) severely threatens human health and life span. An effective therapeutic strategy has not been established because we do not clearly know its pathogenesis. Here, we report that ceramide and sterol O-acyltransferase 1 (SOAT1) have roles in both spontaneous and chemical-induced...

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Detalles Bibliográficos
Autores principales: Zhu, Yahui, Gu, Li, Lin, Xi, Zhang, Jinmiao, Tang, Yi, Zhou, Xinyi, Lu, Bingjun, Lin, Xingrong, Liu, Cheng, Prochownik, Edward V., Li, Youjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855812/
https://www.ncbi.nlm.nih.gov/pubmed/34914638
http://dx.doi.org/10.1172/jci.insight.150607

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