4PBA reduces growth deficiency in osteogenesis imperfecta by enhancing transition of hypertrophic chondrocytes to osteoblasts

Short stature is a major skeletal phenotype in osteogenesis imperfecta (OI), a genetic disorder mainly caused by mutations in genes encoding type I collagen. However, the underlying mechanism is poorly understood, and no effective treatment is available. In OI mice that carry a G610C mutation in COL...

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Detalles Bibliográficos
Autores principales: Scheiber, Amanda L., Wilkinson, Kevin J., Suzuki, Akiko, Enomoto-Iwamoto, Motomi, Kaito, Takashi, Cheah, Kathryn S.E., Iwamoto, Masahiro, Leikin, Sergey, Otsuru, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855815/
https://www.ncbi.nlm.nih.gov/pubmed/34990412
http://dx.doi.org/10.1172/jci.insight.149636

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