Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure yet has few pharmacologic therapies, reflecting the mechanistic heterogeneity of lung injury. We hypothesized that damage to the alveolar epithelial glycocalyx, a layer of glycosaminoglycans interposed between the ep...

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Detalles Bibliográficos
Autores principales: Rizzo, Alicia N., Haeger, Sarah M., Oshima, Kaori, Yang, Yimu, Wallbank, Alison M., Jin, Ying, Lettau, Marie, McCaig, Lynda A., Wickersham, Nancy E., McNeil, J. Brennan, Zakharevich, Igor, McMurtry, Sarah A., Langouët-Astrié, Christophe J., Kopf, Katrina W., Voelker, Dennis R., Hansen, Kirk C., Shaver, Ciara M., Kerchberger, V. Eric, Peterson, Ryan A., Kuebler, Wolfgang M., Ochs, Matthias, Veldhuizen, Ruud A.W., Smith, Bradford J., Ware, Lorraine B., Bastarache, Julie A., Schmidt, Eric P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855818/
https://www.ncbi.nlm.nih.gov/pubmed/34874923
http://dx.doi.org/10.1172/jci.insight.154573

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