mTOR inhibition prevents angiotensin II–induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice

Aortic dissection and rupture are triggered by decreased vascular wall strength and/or increased mechanical loads. We investigated the role of mTOR signaling in aortopathy using a well-described model of angiotensin II–induced dissection, aneurysm, or rupture of the suprarenal abdominal aorta in Apo...

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Detalles Bibliográficos
Autores principales: He, Changshun, Jiang, Bo, Wang, Mo, Ren, Pengwei, Murtada, Sae-Il, Caulk, Alexander W., Li, Guangxin, Qin, Lingfeng, Assi, Roland, Lovoulos, Constantinos J., Schwartz, Martin A., Humphrey, Jay D., Tellides, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855820/
https://www.ncbi.nlm.nih.gov/pubmed/35132962
http://dx.doi.org/10.1172/jci.insight.155815

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