Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice

Ca(2+)/calmodulin-stimulated group I adenylyl cyclase (AC) isoforms AC1 and AC8 have been involved in nociceptive processing and morphine responses. However, whether AC3, another member of group I ACs, is involved in nociceptive transmission and regulates opioid receptor signaling remains elusive. H...

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Detalles Bibliográficos
Autores principales: Zhang, Wen-Wen, Cao, Hong, Li, Yang, Fu, Xian-Jun, Zhang, Yu-Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855833/
https://www.ncbi.nlm.nih.gov/pubmed/34914639
http://dx.doi.org/10.1172/jci.insight.153191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855833/
https://www.ncbi.nlm.nih.gov/pubmed/34914639
http://dx.doi.org/10.1172/jci.insight.153191

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