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Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDA) is an extremely metastatic and lethal disease. Here, in both murine and human PDA, we demonstrate that extracellular matrix architecture regulates cell extrusion and subsequent invasion from intact ductal structures through tumor-associated collagen signatures...

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Detalles Bibliográficos
Autores principales:	Ray, Arja, Callaway, Mackenzie K., Rodríguez-Merced, Nelson J., Crampton, Alexandra L., Carlson, Marjorie, Emme, Kenneth B., Ensminger, Ethan A., Kinne, Alexander A., Schrope, Jonathan H., Rasmussen, Haley R., Jiang, Hong, DeNardo, David G., Wood, David K., Provenzano, Paolo P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855836/ https://www.ncbi.nlm.nih.gov/pubmed/34914633 http://dx.doi.org/10.1172/jci.insight.150330

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