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Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans

BACKGROUND: Adenovirus-vectored (Ad-vectored) vaccines are typically administered via i.m. injection to humans and are incapable of inducing respiratory mucosal immunity. However, aerosol delivery of Ad-vectored vaccines remains poorly characterized, and its ability to induce mucosal immunity in hum...

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Detalles Bibliográficos
Autores principales:	Jeyanathan, Mangalakumari, Fritz, Dominik K., Afkhami, Sam, Aguirre, Emilio, Howie, Karen J., Zganiacz, Anna, Dvorkin-Gheva, Anna, Thompson, Michael R., Silver, Richard F., Cusack, Ruth P., Lichty, Brian D., O’Byrne, Paul M., Kolb, Martin, Medina, Maria Fe C., Dolovich, Myrna B., Satia, Imran, Gauvreau, Gail M., Xing, Zhou, Smaill, Fiona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Clinical Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855837/ https://www.ncbi.nlm.nih.gov/pubmed/34990408 http://dx.doi.org/10.1172/jci.insight.155655

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