MeCP2-induced heterochromatin organization is driven by oligomerization-based liquid–liquid phase separation and restricted by DNA methylation

Heterochromatin is the highly compacted form of chromatin with various condensation levels hallmarked by high DNA methylation. MeCP2 is mostly known as a DNA methylation reader but has also been reported as a heterochromatin organizer. Here, we combine liquid–liquid phase separation (LLPS) analysis...

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Detalles Bibliográficos
Autores principales: Zhang, Hui, Romero, Hector, Schmidt, Annika, Gagova, Katalina, Qin, Weihua, Bertulat, Bianca, Lehmkuhl, Anne, Milden, Manuela, Eck, Malte, Meckel, Tobias, Leonhardt, Heinrich, Cardoso, M. Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855868/
https://www.ncbi.nlm.nih.gov/pubmed/35156529
http://dx.doi.org/10.1080/19491034.2021.2024691

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