The role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common type of liver malignant tumor, with high recurrence and mortality rates. Mesenchymal stem cells (MSCs) are multipotent cells that can be recruited into the tumor microenvironment (TME). What is known, TME plays a vital part in tumor progression. In r...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoli, Li, Na, Zhu, Ying, Wen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855904/
https://www.ncbi.nlm.nih.gov/pubmed/34981659
http://dx.doi.org/10.1002/cam4.4521
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author Zhang, Xiaoli
Li, Na
Zhu, Ying
Wen, Wei
author_facet Zhang, Xiaoli
Li, Na
Zhu, Ying
Wen, Wei
author_sort Zhang, Xiaoli
collection PubMed
description Hepatocellular carcinoma (HCC) is the most common type of liver malignant tumor, with high recurrence and mortality rates. Mesenchymal stem cells (MSCs) are multipotent cells that can be recruited into the tumor microenvironment (TME). What is known, TME plays a vital part in tumor progression. In recent years, accumulating studies have found that MSCs have a dual role of promotion and inhibition in the occurrence and development of HCC. In this review, we analyzed the role of MSCs in TME and summarized the relationship between MSCs and liver cancer stem cells, the molecular signaling pathway mechanisms of MSCs promoting and inhibiting HCC, and the latest research progress of MSCs in the treatment of HCC.
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spelling pubmed-88559042022-02-25 The role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma Zhang, Xiaoli Li, Na Zhu, Ying Wen, Wei Cancer Med Cancer Biology Hepatocellular carcinoma (HCC) is the most common type of liver malignant tumor, with high recurrence and mortality rates. Mesenchymal stem cells (MSCs) are multipotent cells that can be recruited into the tumor microenvironment (TME). What is known, TME plays a vital part in tumor progression. In recent years, accumulating studies have found that MSCs have a dual role of promotion and inhibition in the occurrence and development of HCC. In this review, we analyzed the role of MSCs in TME and summarized the relationship between MSCs and liver cancer stem cells, the molecular signaling pathway mechanisms of MSCs promoting and inhibiting HCC, and the latest research progress of MSCs in the treatment of HCC. John Wiley and Sons Inc. 2022-01-03 /pmc/articles/PMC8855904/ /pubmed/34981659 http://dx.doi.org/10.1002/cam4.4521 Text en © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Biology
Zhang, Xiaoli
Li, Na
Zhu, Ying
Wen, Wei
The role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma
title The role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma
title_full The role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma
title_fullStr The role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma
title_full_unstemmed The role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma
title_short The role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma
title_sort role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855904/
https://www.ncbi.nlm.nih.gov/pubmed/34981659
http://dx.doi.org/10.1002/cam4.4521
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