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Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study

BACKGROUND: Literature with regard to coronavirus disease 2019 (COVID-19) associated morbidities and the risk factors for death are still emerging. In this study, we investigated the presence of kidney damage markers and their predictive value for survival among hospitalized subjects with COVID-19....

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Autores principales: Temiz, Mustafa Zafer, Hacibey, Ibrahim, Yazar, Ramazan Omer, Sevdi, Mehmet Salih, Kucuk, Suat Hayri, Alkurt, Gizem, Doganay, Levent, Dinler Doganay, Gizem, Dincer, Muhammet Murat, Yuruk, Emrah, Erkalp, Kerem, Muslumanoglu, Ahmet Yaser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856025/
https://www.ncbi.nlm.nih.gov/pubmed/35172674
http://dx.doi.org/10.1080/0886022X.2022.2032743
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author Temiz, Mustafa Zafer
Hacibey, Ibrahim
Yazar, Ramazan Omer
Sevdi, Mehmet Salih
Kucuk, Suat Hayri
Alkurt, Gizem
Doganay, Levent
Dinler Doganay, Gizem
Dincer, Muhammet Murat
Yuruk, Emrah
Erkalp, Kerem
Muslumanoglu, Ahmet Yaser
author_facet Temiz, Mustafa Zafer
Hacibey, Ibrahim
Yazar, Ramazan Omer
Sevdi, Mehmet Salih
Kucuk, Suat Hayri
Alkurt, Gizem
Doganay, Levent
Dinler Doganay, Gizem
Dincer, Muhammet Murat
Yuruk, Emrah
Erkalp, Kerem
Muslumanoglu, Ahmet Yaser
author_sort Temiz, Mustafa Zafer
collection PubMed
description BACKGROUND: Literature with regard to coronavirus disease 2019 (COVID-19) associated morbidities and the risk factors for death are still emerging. In this study, we investigated the presence of kidney damage markers and their predictive value for survival among hospitalized subjects with COVID-19. METHODS: Forty-seven participants was included and grouped as: ‘COVID-19 patients before treatment’, ‘COVID-19 patients after treatment’, ‘COVID-19 patients under treatment in intensive care unit (ICU)’, and ‘controls’. Kidney function tests and several kidney injury biomarkers were compared between the groups. Cumulative rates of death from COVID-19 were determined using the Kaplan–Meier method. The associations between covariates including kidney injury markers and death from COVID-19 were examined, as well. RESULTS: Serum creatinine and cystatin C levels, urine Kidney Injury Molecule-1 (KIM-1)/creatinine ratio, and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), CKD-EPI cystatin C, and CKD-EPI creatinine–cystatin C levels demonstrated significant difference among the groups. The most significant difference was noted between the groups ‘COVID-19 patients before treatment’ and ‘COVID-19 patients under treatment in ICU’. Advancing age, proteinuria, elevated serum cystatin C, and urine KIM-1/creatinine ratio were all significant univariate correlates of death (p < 0.05, for all). However, only elevated urine KIM-1/creatinine ratio retained significance in an age, sex, and comorbidities adjusted multivariable Cox regression (OR 6.11; 95% CI: 1.22–30.53; p = 0.02), whereas serum cystatin C showing only a statistically non-significant trend (OR 1.42; 95% CI: 0.00–2.52; p = 0.09). CONCLUSIONS: Our findings clearly demonstrated the acute kidney injury related to COVID-19. Moreover, urine KIM-1/creatinine ratio was associated with COVID-19 specific death.
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spelling pubmed-88560252022-02-19 Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study Temiz, Mustafa Zafer Hacibey, Ibrahim Yazar, Ramazan Omer Sevdi, Mehmet Salih Kucuk, Suat Hayri Alkurt, Gizem Doganay, Levent Dinler Doganay, Gizem Dincer, Muhammet Murat Yuruk, Emrah Erkalp, Kerem Muslumanoglu, Ahmet Yaser Ren Fail Clinical Study BACKGROUND: Literature with regard to coronavirus disease 2019 (COVID-19) associated morbidities and the risk factors for death are still emerging. In this study, we investigated the presence of kidney damage markers and their predictive value for survival among hospitalized subjects with COVID-19. METHODS: Forty-seven participants was included and grouped as: ‘COVID-19 patients before treatment’, ‘COVID-19 patients after treatment’, ‘COVID-19 patients under treatment in intensive care unit (ICU)’, and ‘controls’. Kidney function tests and several kidney injury biomarkers were compared between the groups. Cumulative rates of death from COVID-19 were determined using the Kaplan–Meier method. The associations between covariates including kidney injury markers and death from COVID-19 were examined, as well. RESULTS: Serum creatinine and cystatin C levels, urine Kidney Injury Molecule-1 (KIM-1)/creatinine ratio, and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), CKD-EPI cystatin C, and CKD-EPI creatinine–cystatin C levels demonstrated significant difference among the groups. The most significant difference was noted between the groups ‘COVID-19 patients before treatment’ and ‘COVID-19 patients under treatment in ICU’. Advancing age, proteinuria, elevated serum cystatin C, and urine KIM-1/creatinine ratio were all significant univariate correlates of death (p < 0.05, for all). However, only elevated urine KIM-1/creatinine ratio retained significance in an age, sex, and comorbidities adjusted multivariable Cox regression (OR 6.11; 95% CI: 1.22–30.53; p = 0.02), whereas serum cystatin C showing only a statistically non-significant trend (OR 1.42; 95% CI: 0.00–2.52; p = 0.09). CONCLUSIONS: Our findings clearly demonstrated the acute kidney injury related to COVID-19. Moreover, urine KIM-1/creatinine ratio was associated with COVID-19 specific death. Taylor & Francis 2022-02-16 /pmc/articles/PMC8856025/ /pubmed/35172674 http://dx.doi.org/10.1080/0886022X.2022.2032743 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Temiz, Mustafa Zafer
Hacibey, Ibrahim
Yazar, Ramazan Omer
Sevdi, Mehmet Salih
Kucuk, Suat Hayri
Alkurt, Gizem
Doganay, Levent
Dinler Doganay, Gizem
Dincer, Muhammet Murat
Yuruk, Emrah
Erkalp, Kerem
Muslumanoglu, Ahmet Yaser
Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study
title Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study
title_full Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study
title_fullStr Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study
title_full_unstemmed Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study
title_short Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study
title_sort altered kidney function induced by sars-cov-2 infection and acute kidney damage markers predict survival outcomes of covid-19 patients: a prospective pilot study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856025/
https://www.ncbi.nlm.nih.gov/pubmed/35172674
http://dx.doi.org/10.1080/0886022X.2022.2032743
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