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Construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy

Chemodynamic therapy (CDT) by triggering Fenton reaction or Fenton-like reaction to generate hazardous hydroxyl radical (•OH), is a promising strategy to selectively inhibit tumors with higher H(2)O(2) levels and relatively acidic microenvironment. Current Fe-based Fenton nanocatalysts mostly depend...

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Autores principales: Shi, Zhaoqing, Tang, Jing, Lin, Chuchu, Chen, Ting, Zhang, Fan, Huang, Yuxing, Luan, Ping, Xin, Zhuo, Li, Qianqian, Mei, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856058/
https://www.ncbi.nlm.nih.gov/pubmed/35174748
http://dx.doi.org/10.1080/10717544.2022.2039810
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author Shi, Zhaoqing
Tang, Jing
Lin, Chuchu
Chen, Ting
Zhang, Fan
Huang, Yuxing
Luan, Ping
Xin, Zhuo
Li, Qianqian
Mei, Lin
author_facet Shi, Zhaoqing
Tang, Jing
Lin, Chuchu
Chen, Ting
Zhang, Fan
Huang, Yuxing
Luan, Ping
Xin, Zhuo
Li, Qianqian
Mei, Lin
author_sort Shi, Zhaoqing
collection PubMed
description Chemodynamic therapy (CDT) by triggering Fenton reaction or Fenton-like reaction to generate hazardous hydroxyl radical (•OH), is a promising strategy to selectively inhibit tumors with higher H(2)O(2) levels and relatively acidic microenvironment. Current Fe-based Fenton nanocatalysts mostly depend on slowly releasing iron ions from Fe or Fe oxide-based nanoparticles, which leads to a limited rate of Fenton reaction. Herein, we employed black phosphorene nanosheets (BPNS), a biocompatible and biodegradable photothermal material, to develop iron-mineralized black phosphorene nanosheet (BPFe) by in situ deposition method for chemodynamic and photothermal combination cancer therapy. This study demonstrated that the BPFe could selectively increase cytotoxic ·OH in tumor cells whereas having no influence on normal cells. The IC(50) of BPFe for tested tumor cells was about 3–6 μg/mL, which was at least one order of magnitude lower than previous Fe-based Fenton nanocatalysts. The low H(2)O(2) level in normal mammalian cells guaranteed the rare cytotoxicity of BPFe. Moreover, the combination of photothermal therapy (PTT) with CDT based on BPFe was proved to kill tumors more potently with spatiotemporal accuracy, which exhibited excellent anti-tumor effects in xenografted MCF-7 tumor mice models.
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spelling pubmed-88560582022-02-19 Construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy Shi, Zhaoqing Tang, Jing Lin, Chuchu Chen, Ting Zhang, Fan Huang, Yuxing Luan, Ping Xin, Zhuo Li, Qianqian Mei, Lin Drug Deliv Research Article Chemodynamic therapy (CDT) by triggering Fenton reaction or Fenton-like reaction to generate hazardous hydroxyl radical (•OH), is a promising strategy to selectively inhibit tumors with higher H(2)O(2) levels and relatively acidic microenvironment. Current Fe-based Fenton nanocatalysts mostly depend on slowly releasing iron ions from Fe or Fe oxide-based nanoparticles, which leads to a limited rate of Fenton reaction. Herein, we employed black phosphorene nanosheets (BPNS), a biocompatible and biodegradable photothermal material, to develop iron-mineralized black phosphorene nanosheet (BPFe) by in situ deposition method for chemodynamic and photothermal combination cancer therapy. This study demonstrated that the BPFe could selectively increase cytotoxic ·OH in tumor cells whereas having no influence on normal cells. The IC(50) of BPFe for tested tumor cells was about 3–6 μg/mL, which was at least one order of magnitude lower than previous Fe-based Fenton nanocatalysts. The low H(2)O(2) level in normal mammalian cells guaranteed the rare cytotoxicity of BPFe. Moreover, the combination of photothermal therapy (PTT) with CDT based on BPFe was proved to kill tumors more potently with spatiotemporal accuracy, which exhibited excellent anti-tumor effects in xenografted MCF-7 tumor mice models. Taylor & Francis 2022-02-17 /pmc/articles/PMC8856058/ /pubmed/35174748 http://dx.doi.org/10.1080/10717544.2022.2039810 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shi, Zhaoqing
Tang, Jing
Lin, Chuchu
Chen, Ting
Zhang, Fan
Huang, Yuxing
Luan, Ping
Xin, Zhuo
Li, Qianqian
Mei, Lin
Construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy
title Construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy
title_full Construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy
title_fullStr Construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy
title_full_unstemmed Construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy
title_short Construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy
title_sort construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856058/
https://www.ncbi.nlm.nih.gov/pubmed/35174748
http://dx.doi.org/10.1080/10717544.2022.2039810
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