Cargando…

Effect of Helicobacter pylori-Associated Chronic Gastritis on Autonomous Activity and Sleep Quality in Mice

Many reports have shown that patients with Hp-associated chronic gastritis exhibit anxiety and poor sleep quality. However, less is known about the effects and specific manifestations of Hp-associated chronic gastritis on autonomous activity and sleep quality in animals. Here, we investigated the ef...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Haihua, Zheng, Wenlong, Zhang, Ling, Lin, Tangtang, Tang, Yang, Hu, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856107/
https://www.ncbi.nlm.nih.gov/pubmed/35185560
http://dx.doi.org/10.3389/fphar.2022.785105
_version_ 1784653773836124160
author Liu, Haihua
Zheng, Wenlong
Zhang, Ling
Lin, Tangtang
Tang, Yang
Hu, Ling
author_facet Liu, Haihua
Zheng, Wenlong
Zhang, Ling
Lin, Tangtang
Tang, Yang
Hu, Ling
author_sort Liu, Haihua
collection PubMed
description Many reports have shown that patients with Hp-associated chronic gastritis exhibit anxiety and poor sleep quality. However, less is known about the effects and specific manifestations of Hp-associated chronic gastritis on autonomous activity and sleep quality in animals. Here, we investigated the effect of Helicobacter pylori (Hp)-associated chronic gastritis on autonomous activity and sleep quality in mice. To do this, a Hp-associated chronic gastritis mouse model was first established, then analyzed for autonomous activity, relative to controls, for 15 min using an autonomous activity tester. Next, sleep quality of mice was detected by sodium pentobarbital-induced sleep experiment and results compared between groups. The results showed that male mice in the model group exhibited higher activity counts but lower forelimb lift counts, relative to those in the control group, although there were no significant differences (all p > .05). Conversely, female mice in the model group recorded lower activity counts, albeit at no significant difference (p > .05), and significantly lower counts of forelimb lift (p < .05), relative to those in the control group. Notably, male mice in the model group had longer sleep latency and shorter sleep duration than those in the control group, albeit at no significant differences (all p > .05). On the other hand, female mice in the model group recorded significantly longer sleep latency as well as shorter sleep duration compared to those in the control group (all p < .01). We conclude that Hp-associated chronic gastritis exerts certain effects on autonomous activity and sleep quality of mice in a gender-dependent manner. Notably, female mice with Hp-associated chronic gastritis had lower activity and forelimb lift counts, as well as prolonged sleep latency, and shortened sleep duration. These effects were all statistically significant except for activity counts.
format Online
Article
Text
id pubmed-8856107
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-88561072022-02-19 Effect of Helicobacter pylori-Associated Chronic Gastritis on Autonomous Activity and Sleep Quality in Mice Liu, Haihua Zheng, Wenlong Zhang, Ling Lin, Tangtang Tang, Yang Hu, Ling Front Pharmacol Pharmacology Many reports have shown that patients with Hp-associated chronic gastritis exhibit anxiety and poor sleep quality. However, less is known about the effects and specific manifestations of Hp-associated chronic gastritis on autonomous activity and sleep quality in animals. Here, we investigated the effect of Helicobacter pylori (Hp)-associated chronic gastritis on autonomous activity and sleep quality in mice. To do this, a Hp-associated chronic gastritis mouse model was first established, then analyzed for autonomous activity, relative to controls, for 15 min using an autonomous activity tester. Next, sleep quality of mice was detected by sodium pentobarbital-induced sleep experiment and results compared between groups. The results showed that male mice in the model group exhibited higher activity counts but lower forelimb lift counts, relative to those in the control group, although there were no significant differences (all p > .05). Conversely, female mice in the model group recorded lower activity counts, albeit at no significant difference (p > .05), and significantly lower counts of forelimb lift (p < .05), relative to those in the control group. Notably, male mice in the model group had longer sleep latency and shorter sleep duration than those in the control group, albeit at no significant differences (all p > .05). On the other hand, female mice in the model group recorded significantly longer sleep latency as well as shorter sleep duration compared to those in the control group (all p < .01). We conclude that Hp-associated chronic gastritis exerts certain effects on autonomous activity and sleep quality of mice in a gender-dependent manner. Notably, female mice with Hp-associated chronic gastritis had lower activity and forelimb lift counts, as well as prolonged sleep latency, and shortened sleep duration. These effects were all statistically significant except for activity counts. Frontiers Media S.A. 2022-02-04 /pmc/articles/PMC8856107/ /pubmed/35185560 http://dx.doi.org/10.3389/fphar.2022.785105 Text en Copyright © 2022 Liu, Zheng, Zhang, Lin, Tang and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Liu, Haihua
Zheng, Wenlong
Zhang, Ling
Lin, Tangtang
Tang, Yang
Hu, Ling
Effect of Helicobacter pylori-Associated Chronic Gastritis on Autonomous Activity and Sleep Quality in Mice
title Effect of Helicobacter pylori-Associated Chronic Gastritis on Autonomous Activity and Sleep Quality in Mice
title_full Effect of Helicobacter pylori-Associated Chronic Gastritis on Autonomous Activity and Sleep Quality in Mice
title_fullStr Effect of Helicobacter pylori-Associated Chronic Gastritis on Autonomous Activity and Sleep Quality in Mice
title_full_unstemmed Effect of Helicobacter pylori-Associated Chronic Gastritis on Autonomous Activity and Sleep Quality in Mice
title_short Effect of Helicobacter pylori-Associated Chronic Gastritis on Autonomous Activity and Sleep Quality in Mice
title_sort effect of helicobacter pylori-associated chronic gastritis on autonomous activity and sleep quality in mice
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856107/
https://www.ncbi.nlm.nih.gov/pubmed/35185560
http://dx.doi.org/10.3389/fphar.2022.785105
work_keys_str_mv AT liuhaihua effectofhelicobacterpyloriassociatedchronicgastritisonautonomousactivityandsleepqualityinmice
AT zhengwenlong effectofhelicobacterpyloriassociatedchronicgastritisonautonomousactivityandsleepqualityinmice
AT zhangling effectofhelicobacterpyloriassociatedchronicgastritisonautonomousactivityandsleepqualityinmice
AT lintangtang effectofhelicobacterpyloriassociatedchronicgastritisonautonomousactivityandsleepqualityinmice
AT tangyang effectofhelicobacterpyloriassociatedchronicgastritisonautonomousactivityandsleepqualityinmice
AT huling effectofhelicobacterpyloriassociatedchronicgastritisonautonomousactivityandsleepqualityinmice