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Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs

CONTEXT: Patients with non-alcoholic steatohepatitis (NASH) may have a simultaneous intake of pravastatin and evodiamine-containing herbs. OBJECTIVE: The effect of evodiamine on the pharmacokinetics of pravastatin and its potential mechanisms were investigated in NASH rats. MATERIALS AND METHODS: Th...

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Detalles Bibliográficos
Autores principales:	Liang, Ruifeng, Ge, Wenjing, Li, Bingjie, Cui, Weifeng, Ma, Xiaofan, Pan, Yuying, Li, Gengsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856114/ https://www.ncbi.nlm.nih.gov/pubmed/35171063 http://dx.doi.org/10.1080/13880209.2022.2036767

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