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SGLT2 inhibitors therapy protects glucotoxicity-induced β-cell failure in a mouse model of human K(ATP)-induced diabetes through mitigation of oxidative and ER stress
Progressive loss of pancreatic β-cell functional mass and anti-diabetic drug responsivity are classic findings in diabetes, frequently attributed to compensatory insulin hypersecretion and β-cell exhaustion. However, loss of β-cell mass and identity still occurs in mouse models of human K(ATP)-gain-...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856523/ https://www.ncbi.nlm.nih.gov/pubmed/35180212 http://dx.doi.org/10.1371/journal.pone.0258054 |