Cargando…
Congenital malaria: Frequency and epidemiology in Colombia, 2009-2020
Congenital Malaria (CM) is an underestimated and under-researched problem in Colombia, despite its severe clinical, epidemiological, economic, and public health consequences. The objective was to determine the general frequency of CM, the specific frequency of CM by diagnostic test and plasmodial sp...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856554/ https://www.ncbi.nlm.nih.gov/pubmed/35180230 http://dx.doi.org/10.1371/journal.pone.0263451 |
_version_ | 1784653873498030080 |
---|---|
author | Cardona-Arias, Jaiberth Antonio Carmona-Fonseca, Jaime |
author_facet | Cardona-Arias, Jaiberth Antonio Carmona-Fonseca, Jaime |
author_sort | Cardona-Arias, Jaiberth Antonio |
collection | PubMed |
description | Congenital Malaria (CM) is an underestimated and under-researched problem in Colombia, despite its severe clinical, epidemiological, economic, and public health consequences. The objective was to determine the general frequency of CM, the specific frequency of CM by diagnostic test and plasmodial species, and identify its associated factors. A retrospective study was carried out using the records of 567 newborns. qPCR and Thick Blood Smear (TBS) were performed. The frequency of infection was determined with a 95% confidence interval. Associated factors were identified by non-parametric tests and odds ratios; the confusion was controlled with a logistic regression model. All cases corresponded to submicroscopic CM (negative with TBS and positive with PCR), and the frequency was 12.2% (95%CI = 9.4–14.9). The detection was statistically higher in the umbilical cord with 16,2% (95%CI = 12.4–19.9) versus peripheral blood of the newborn with 2.2% (95%CI = 0.7–4.9). CM was statistically higher in newborn whose mothers had malaria in the last year, gestational and placental malaria. The median birth weight in newborn infected with CM was lower compared to the one of healthy neonates. Because the control program in Colombia is based on TBS, it must be improved with the inclusion of other tests that allow the detection of submicroscopic CM. In addition, the program has other limitations such as do not have specific actions for pregnant women and have a passive surveillance system. These difficulties do not allow to show the magnitude of CM, its consequences on neonatal and infant health, constituting a serious problem of health injustice. |
format | Online Article Text |
id | pubmed-8856554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-88565542022-02-19 Congenital malaria: Frequency and epidemiology in Colombia, 2009-2020 Cardona-Arias, Jaiberth Antonio Carmona-Fonseca, Jaime PLoS One Research Article Congenital Malaria (CM) is an underestimated and under-researched problem in Colombia, despite its severe clinical, epidemiological, economic, and public health consequences. The objective was to determine the general frequency of CM, the specific frequency of CM by diagnostic test and plasmodial species, and identify its associated factors. A retrospective study was carried out using the records of 567 newborns. qPCR and Thick Blood Smear (TBS) were performed. The frequency of infection was determined with a 95% confidence interval. Associated factors were identified by non-parametric tests and odds ratios; the confusion was controlled with a logistic regression model. All cases corresponded to submicroscopic CM (negative with TBS and positive with PCR), and the frequency was 12.2% (95%CI = 9.4–14.9). The detection was statistically higher in the umbilical cord with 16,2% (95%CI = 12.4–19.9) versus peripheral blood of the newborn with 2.2% (95%CI = 0.7–4.9). CM was statistically higher in newborn whose mothers had malaria in the last year, gestational and placental malaria. The median birth weight in newborn infected with CM was lower compared to the one of healthy neonates. Because the control program in Colombia is based on TBS, it must be improved with the inclusion of other tests that allow the detection of submicroscopic CM. In addition, the program has other limitations such as do not have specific actions for pregnant women and have a passive surveillance system. These difficulties do not allow to show the magnitude of CM, its consequences on neonatal and infant health, constituting a serious problem of health injustice. Public Library of Science 2022-02-18 /pmc/articles/PMC8856554/ /pubmed/35180230 http://dx.doi.org/10.1371/journal.pone.0263451 Text en © 2022 Cardona-Arias, Carmona-Fonseca https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Cardona-Arias, Jaiberth Antonio Carmona-Fonseca, Jaime Congenital malaria: Frequency and epidemiology in Colombia, 2009-2020 |
title | Congenital malaria: Frequency and epidemiology in Colombia, 2009-2020 |
title_full | Congenital malaria: Frequency and epidemiology in Colombia, 2009-2020 |
title_fullStr | Congenital malaria: Frequency and epidemiology in Colombia, 2009-2020 |
title_full_unstemmed | Congenital malaria: Frequency and epidemiology in Colombia, 2009-2020 |
title_short | Congenital malaria: Frequency and epidemiology in Colombia, 2009-2020 |
title_sort | congenital malaria: frequency and epidemiology in colombia, 2009-2020 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856554/ https://www.ncbi.nlm.nih.gov/pubmed/35180230 http://dx.doi.org/10.1371/journal.pone.0263451 |
work_keys_str_mv | AT cardonaariasjaiberthantonio congenitalmalariafrequencyandepidemiologyincolombia20092020 AT carmonafonsecajaime congenitalmalariafrequencyandepidemiologyincolombia20092020 |