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The histone demethylase PHF8 regulates TGFβ signaling and promotes melanoma metastasis

The contribution of epigenetic dysregulation to metastasis remains understudied. Through a meta-analysis of gene expression datasets followed by a mini-screen, we identified Plant Homeodomain Finger protein 8 (PHF8), a histone demethylase of the Jumonji C protein family, as a previously unidentified...

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Detalles Bibliográficos
Autores principales:	Moubarak, Rana S., de Pablos-Aragoneses, Ana, Ortiz-Barahona, Vanessa, Gong, Yixiao, Gowen, Michael, Dolgalev, Igor, Shadaloey, Sorin A. A., Argibay, Diana, Karz, Alcida, Von Itter, Richard, Vega-Sáenz de Miera, Eleazar Carmelo, Sokolova, Elena, Darvishian, Farbod, Tsirigos, Aristotelis, Osman, Iman, Hernando, Eva
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856617/ https://www.ncbi.nlm.nih.gov/pubmed/35179962 http://dx.doi.org/10.1126/sciadv.abi7127

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