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COVID-19 and Mitochondrial Non-Coding RNAs: New Insights From Published Data

Scientists all around the world are working to investigate new ways to prevent and treat COVID-19, and recent research has been focusing on the effects of a syndrome commonly called “long COVID.” People affected by this syndrome usually suffer from symptoms like the ones observed in several types of...

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Autor principal: Pozzi, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856670/
https://www.ncbi.nlm.nih.gov/pubmed/35185603
http://dx.doi.org/10.3389/fphys.2021.805005
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author Pozzi, Andrea
author_facet Pozzi, Andrea
author_sort Pozzi, Andrea
collection PubMed
description Scientists all around the world are working to investigate new ways to prevent and treat COVID-19, and recent research has been focusing on the effects of a syndrome commonly called “long COVID.” People affected by this syndrome usually suffer from symptoms like the ones observed in several types of fatigue syndrome. As these syndromes are often linked to mitochondrial dysfunction, researchers hypothesized that a dysfunction in the mitochondrial metabolism might be part of the causes of long COVID. However, while there are a few studies investigating the effect of SARS-CoV-2 infection on mitochondrial metabolism, the effect on the transcription of mitochondrial non-coding RNAs has not been investigated yet. Thus, using publicly available data, I explored the effect of SARS-CoV-2 on the expression of several mitochondrial non-coding RNAs in patients recovering from COVID-19. No change in the expression of long non-coding RNAs was detected at any stage of the infection, but up to 43 small mitochondrial RNAs have their expression altered during the recovery from COVID-19. This result suggests that the SARS-CoV-2 infection somehow affected the metabolism of small mitochondrial RNAs specifically without altering the overall mitochondrial transcription. Despite these being only preliminary results on a small cohort, the analyses clearly showed that individuals infected by SARS-CoV-2 retain an altered expression of these small RNAs. This persistent alteration in the expression of small mitochondrial RNAs might be involved in the long COVID syndrome and further studies are needed to confirm the possibility.
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spelling pubmed-88566702022-02-19 COVID-19 and Mitochondrial Non-Coding RNAs: New Insights From Published Data Pozzi, Andrea Front Physiol Physiology Scientists all around the world are working to investigate new ways to prevent and treat COVID-19, and recent research has been focusing on the effects of a syndrome commonly called “long COVID.” People affected by this syndrome usually suffer from symptoms like the ones observed in several types of fatigue syndrome. As these syndromes are often linked to mitochondrial dysfunction, researchers hypothesized that a dysfunction in the mitochondrial metabolism might be part of the causes of long COVID. However, while there are a few studies investigating the effect of SARS-CoV-2 infection on mitochondrial metabolism, the effect on the transcription of mitochondrial non-coding RNAs has not been investigated yet. Thus, using publicly available data, I explored the effect of SARS-CoV-2 on the expression of several mitochondrial non-coding RNAs in patients recovering from COVID-19. No change in the expression of long non-coding RNAs was detected at any stage of the infection, but up to 43 small mitochondrial RNAs have their expression altered during the recovery from COVID-19. This result suggests that the SARS-CoV-2 infection somehow affected the metabolism of small mitochondrial RNAs specifically without altering the overall mitochondrial transcription. Despite these being only preliminary results on a small cohort, the analyses clearly showed that individuals infected by SARS-CoV-2 retain an altered expression of these small RNAs. This persistent alteration in the expression of small mitochondrial RNAs might be involved in the long COVID syndrome and further studies are needed to confirm the possibility. Frontiers Media S.A. 2022-02-04 /pmc/articles/PMC8856670/ /pubmed/35185603 http://dx.doi.org/10.3389/fphys.2021.805005 Text en Copyright © 2022 Pozzi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Pozzi, Andrea
COVID-19 and Mitochondrial Non-Coding RNAs: New Insights From Published Data
title COVID-19 and Mitochondrial Non-Coding RNAs: New Insights From Published Data
title_full COVID-19 and Mitochondrial Non-Coding RNAs: New Insights From Published Data
title_fullStr COVID-19 and Mitochondrial Non-Coding RNAs: New Insights From Published Data
title_full_unstemmed COVID-19 and Mitochondrial Non-Coding RNAs: New Insights From Published Data
title_short COVID-19 and Mitochondrial Non-Coding RNAs: New Insights From Published Data
title_sort covid-19 and mitochondrial non-coding rnas: new insights from published data
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856670/
https://www.ncbi.nlm.nih.gov/pubmed/35185603
http://dx.doi.org/10.3389/fphys.2021.805005
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