Allele-specific genomic data elucidate the role of somatic gain and copy-number neutral loss of heterozygosity in cancer

Pan-cancer studies sketched the genomic landscape of the tumor types spectrum. We delineated the purity- and ploidy-adjusted allele-specific profiles of 4,950 patients across 27 tumor types from the Cancer Genome Atlas (TCGA). Leveraging allele-specific data, we reclassified as loss of heterozygosit...

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Detalles Bibliográficos
Autores principales: Ciani, Yari, Fedrizzi, Tarcisio, Prandi, Davide, Lorenzin, Francesca, Locallo, Alessio, Gasperini, Paola, Franceschini, Gian Marco, Benelli, Matteo, Elemento, Olivier, Fava, Luca L., Inga, Alberto, Demichelis, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856743/
https://www.ncbi.nlm.nih.gov/pubmed/34731645
http://dx.doi.org/10.1016/j.cels.2021.10.001

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