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The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis

Low back pain (LBP) is seriously harmful to human health and produces heavy economic burden. And most scholars hold that intervertebral disc degeneration (IDD) is the primary cause of LBP. With the study of IDD, aberrant expression of gene has become an important pathogenic factor of IDD. Circular R...

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Detalles Bibliográficos
Autores principales: Li, Hao, Tian, Lijun, Li, Jianhua, Li, Yongjin, Du, Lilong, Huo, Zhenxin, Xu, Baoshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856834/
https://www.ncbi.nlm.nih.gov/pubmed/35186669
http://dx.doi.org/10.1155/2022/9550499
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author Li, Hao
Tian, Lijun
Li, Jianhua
Li, Yongjin
Du, Lilong
Huo, Zhenxin
Xu, Baoshan
author_facet Li, Hao
Tian, Lijun
Li, Jianhua
Li, Yongjin
Du, Lilong
Huo, Zhenxin
Xu, Baoshan
author_sort Li, Hao
collection PubMed
description Low back pain (LBP) is seriously harmful to human health and produces heavy economic burden. And most scholars hold that intervertebral disc degeneration (IDD) is the primary cause of LBP. With the study of IDD, aberrant expression of gene has become an important pathogenic factor of IDD. Circular RNAs (circRNAs), as a kind of noncoding RNA (ncRNA), participate in the regulation of genetic transcription and translation and further affect the expression of inflammatory cytokine, metabolism of extracellular matrix (ECM), the proliferation and apoptosis of cells, etc. Therefore, maybe it will become a new therapeutic target for IDD. At present, our understanding of the mechanism of circRNAs in IDD is limited. The purpose of this review is to summarize the mechanism and related signaling pathways of circRNAs in IDD reported in the past. Particularly, the roles of circRNAs in inflammation, ECM metabolism, and apoptosis are emphasized.
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spelling pubmed-88568342022-02-19 The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis Li, Hao Tian, Lijun Li, Jianhua Li, Yongjin Du, Lilong Huo, Zhenxin Xu, Baoshan Anal Cell Pathol (Amst) Review Article Low back pain (LBP) is seriously harmful to human health and produces heavy economic burden. And most scholars hold that intervertebral disc degeneration (IDD) is the primary cause of LBP. With the study of IDD, aberrant expression of gene has become an important pathogenic factor of IDD. Circular RNAs (circRNAs), as a kind of noncoding RNA (ncRNA), participate in the regulation of genetic transcription and translation and further affect the expression of inflammatory cytokine, metabolism of extracellular matrix (ECM), the proliferation and apoptosis of cells, etc. Therefore, maybe it will become a new therapeutic target for IDD. At present, our understanding of the mechanism of circRNAs in IDD is limited. The purpose of this review is to summarize the mechanism and related signaling pathways of circRNAs in IDD reported in the past. Particularly, the roles of circRNAs in inflammation, ECM metabolism, and apoptosis are emphasized. Hindawi 2022-02-11 /pmc/articles/PMC8856834/ /pubmed/35186669 http://dx.doi.org/10.1155/2022/9550499 Text en Copyright © 2022 Hao Li et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Hao
Tian, Lijun
Li, Jianhua
Li, Yongjin
Du, Lilong
Huo, Zhenxin
Xu, Baoshan
The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis
title The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis
title_full The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis
title_fullStr The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis
title_full_unstemmed The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis
title_short The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis
title_sort roles of circrnas in intervertebral disc degeneration: inflammation, extracellular matrix metabolism, and apoptosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856834/
https://www.ncbi.nlm.nih.gov/pubmed/35186669
http://dx.doi.org/10.1155/2022/9550499
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