Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies. To dissect the underlying mechanisms, we combined an engineered ascorbic acid peroxidase (APEX) approach with quantitative affinity purification mass spectrometry (AP-MS) followed by proximity ligation assay (PLA...

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Detalles Bibliográficos
Autores principales: Tracy, Tara E., Madero-Pérez, Jesus, Swaney, Danielle L., Chang, Timothy S., Moritz, Michelle, Konrad, Csaba, Ward, Michael E., Stevenson, Erica, Hüttenhain, Ruth, Kauwe, Grant, Mercedes, Maria, Sweetland-Martin, Lauren, Chen, Xu, Mok, Sue-Ann, Wong, Man Ying, Telpoukhovskaia, Maria, Min, Sang-Won, Wang, Chao, Dongmin Sohn, Peter, Martin, Jordie, Zhou, Yungui, Luo, Wenjie, Trojanowski, John Q., Lee, Virginia M.Y., Gong, Shiaoching, Manfredi, Giovanni, Coppola, Giovanni, Krogan, Nevan J., Geschwind, Daniel H., Gan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857049/
https://www.ncbi.nlm.nih.gov/pubmed/35063084
http://dx.doi.org/10.1016/j.cell.2021.12.041

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