Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients

While exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these beneficial effects. We investigated the influence of e...

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Autores principales: Winker, Matteo, Stössel, Sandra, Neu, Marie Astrid, Lehmann, Nadine, El Malki, Khalifa, Paret, Claudia, Joisten, Niklas, Bloch, Wilhelm, Zimmer, Philipp, Faber, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857093/
https://www.ncbi.nlm.nih.gov/pubmed/34860287
http://dx.doi.org/10.1007/s00520-021-06719-3
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author Winker, Matteo
Stössel, Sandra
Neu, Marie Astrid
Lehmann, Nadine
El Malki, Khalifa
Paret, Claudia
Joisten, Niklas
Bloch, Wilhelm
Zimmer, Philipp
Faber, Jörg
author_facet Winker, Matteo
Stössel, Sandra
Neu, Marie Astrid
Lehmann, Nadine
El Malki, Khalifa
Paret, Claudia
Joisten, Niklas
Bloch, Wilhelm
Zimmer, Philipp
Faber, Jörg
author_sort Winker, Matteo
collection PubMed
description While exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these beneficial effects. We investigated the influence of exercise on the inflammation markers neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic-immune-inflammation index (SII) and associations to patient-reported-outcomes in CCPs in a randomized-controlled trial. Results show associations between inflammation markers and patient-reported outcomes. Compared to the control group, SII was significantly reduced following exercise (p=0.036). Anti-inflammatory effects of exercise are also present in CCPs and may underlie exercise-induced benefits on symptoms. Clinical Trial Registration Number: NCT02612025
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spelling pubmed-88570932022-02-23 Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients Winker, Matteo Stössel, Sandra Neu, Marie Astrid Lehmann, Nadine El Malki, Khalifa Paret, Claudia Joisten, Niklas Bloch, Wilhelm Zimmer, Philipp Faber, Jörg Support Care Cancer Commentary While exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these beneficial effects. We investigated the influence of exercise on the inflammation markers neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic-immune-inflammation index (SII) and associations to patient-reported-outcomes in CCPs in a randomized-controlled trial. Results show associations between inflammation markers and patient-reported outcomes. Compared to the control group, SII was significantly reduced following exercise (p=0.036). Anti-inflammatory effects of exercise are also present in CCPs and may underlie exercise-induced benefits on symptoms. Clinical Trial Registration Number: NCT02612025 Springer Berlin Heidelberg 2021-12-03 2022 /pmc/articles/PMC8857093/ /pubmed/34860287 http://dx.doi.org/10.1007/s00520-021-06719-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Winker, Matteo
Stössel, Sandra
Neu, Marie Astrid
Lehmann, Nadine
El Malki, Khalifa
Paret, Claudia
Joisten, Niklas
Bloch, Wilhelm
Zimmer, Philipp
Faber, Jörg
Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients
title Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients
title_full Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients
title_fullStr Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients
title_full_unstemmed Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients
title_short Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients
title_sort exercise reduces systemic immune inflammation index (sii) in childhood cancer patients
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857093/
https://www.ncbi.nlm.nih.gov/pubmed/34860287
http://dx.doi.org/10.1007/s00520-021-06719-3
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