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Sex differences in brain atrophy and cognitive impairment in Parkinson’s disease patients with and without probable rapid eye movement sleep behavior disorder
BACKGROUND: The presence of rapid eye movement sleep behavior disorder (RBD) contributes to increase cognitive impairment and brain atrophy in Parkinson’s disease (PD), but the impact of sex is unclear. We aimed to investigate sex differences in cognition and brain atrophy in PD patients with and wi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857118/ https://www.ncbi.nlm.nih.gov/pubmed/34345972 http://dx.doi.org/10.1007/s00415-021-10728-x |
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author | Oltra, Javier Segura, Barbara Uribe, Carme Monté-Rubio, Gemma C. Campabadal, Anna Inguanzo, Anna Pardo, Jèssica Marti, Maria J. Compta, Yaroslau Valldeoriola, Francesc Iranzo, Alex Junque, Carme |
author_facet | Oltra, Javier Segura, Barbara Uribe, Carme Monté-Rubio, Gemma C. Campabadal, Anna Inguanzo, Anna Pardo, Jèssica Marti, Maria J. Compta, Yaroslau Valldeoriola, Francesc Iranzo, Alex Junque, Carme |
author_sort | Oltra, Javier |
collection | PubMed |
description | BACKGROUND: The presence of rapid eye movement sleep behavior disorder (RBD) contributes to increase cognitive impairment and brain atrophy in Parkinson’s disease (PD), but the impact of sex is unclear. We aimed to investigate sex differences in cognition and brain atrophy in PD patients with and without probable RBD (pRBD). METHODS: Magnetic resonance imaging and cognition data were obtained for 274 participants from the Parkinson's Progression Marker Initiative database: 79 PD with pRBD (PD-pRBD; male/female, 54/25), 126 PD without pRBD (PD-non pRBD; male/female, 73/53), and 69 healthy controls (male/female, 40/29). FreeSurfer was used to obtain volumetric and cortical thickness data. RESULTS: Males showed greater global cortical and subcortical gray matter atrophy than females in the PD-pRBD group. Significant group-by-sex interactions were found in the pallidum. Structures showing a within-group sex effect in the deep gray matter differed, with significant volume reductions for males in one structure in in PD-non pRBD (brainstem), and three in PD-pRBD (caudate, pallidum and brainstem). Significant group-by-sex interactions were found in Montreal Cognitive Assessment (MoCA) and Symbol Digits Modalities Test (SDMT). Males performed worse than females in MoCA, phonemic fluency and SDMT in the PD-pRBD group. CONCLUSION: Male sex is related to increased cognitive impairment and subcortical atrophy in de novo PD-pRBD. Accordingly, we suggest that sex differences are relevant and should be considered in future clinical and translational research. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-021-10728-x. |
format | Online Article Text |
id | pubmed-8857118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-88571182022-02-23 Sex differences in brain atrophy and cognitive impairment in Parkinson’s disease patients with and without probable rapid eye movement sleep behavior disorder Oltra, Javier Segura, Barbara Uribe, Carme Monté-Rubio, Gemma C. Campabadal, Anna Inguanzo, Anna Pardo, Jèssica Marti, Maria J. Compta, Yaroslau Valldeoriola, Francesc Iranzo, Alex Junque, Carme J Neurol Original Communication BACKGROUND: The presence of rapid eye movement sleep behavior disorder (RBD) contributes to increase cognitive impairment and brain atrophy in Parkinson’s disease (PD), but the impact of sex is unclear. We aimed to investigate sex differences in cognition and brain atrophy in PD patients with and without probable RBD (pRBD). METHODS: Magnetic resonance imaging and cognition data were obtained for 274 participants from the Parkinson's Progression Marker Initiative database: 79 PD with pRBD (PD-pRBD; male/female, 54/25), 126 PD without pRBD (PD-non pRBD; male/female, 73/53), and 69 healthy controls (male/female, 40/29). FreeSurfer was used to obtain volumetric and cortical thickness data. RESULTS: Males showed greater global cortical and subcortical gray matter atrophy than females in the PD-pRBD group. Significant group-by-sex interactions were found in the pallidum. Structures showing a within-group sex effect in the deep gray matter differed, with significant volume reductions for males in one structure in in PD-non pRBD (brainstem), and three in PD-pRBD (caudate, pallidum and brainstem). Significant group-by-sex interactions were found in Montreal Cognitive Assessment (MoCA) and Symbol Digits Modalities Test (SDMT). Males performed worse than females in MoCA, phonemic fluency and SDMT in the PD-pRBD group. CONCLUSION: Male sex is related to increased cognitive impairment and subcortical atrophy in de novo PD-pRBD. Accordingly, we suggest that sex differences are relevant and should be considered in future clinical and translational research. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-021-10728-x. Springer Berlin Heidelberg 2021-08-03 2022 /pmc/articles/PMC8857118/ /pubmed/34345972 http://dx.doi.org/10.1007/s00415-021-10728-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Communication Oltra, Javier Segura, Barbara Uribe, Carme Monté-Rubio, Gemma C. Campabadal, Anna Inguanzo, Anna Pardo, Jèssica Marti, Maria J. Compta, Yaroslau Valldeoriola, Francesc Iranzo, Alex Junque, Carme Sex differences in brain atrophy and cognitive impairment in Parkinson’s disease patients with and without probable rapid eye movement sleep behavior disorder |
title | Sex differences in brain atrophy and cognitive impairment in Parkinson’s disease patients with and without probable rapid eye movement sleep behavior disorder |
title_full | Sex differences in brain atrophy and cognitive impairment in Parkinson’s disease patients with and without probable rapid eye movement sleep behavior disorder |
title_fullStr | Sex differences in brain atrophy and cognitive impairment in Parkinson’s disease patients with and without probable rapid eye movement sleep behavior disorder |
title_full_unstemmed | Sex differences in brain atrophy and cognitive impairment in Parkinson’s disease patients with and without probable rapid eye movement sleep behavior disorder |
title_short | Sex differences in brain atrophy and cognitive impairment in Parkinson’s disease patients with and without probable rapid eye movement sleep behavior disorder |
title_sort | sex differences in brain atrophy and cognitive impairment in parkinson’s disease patients with and without probable rapid eye movement sleep behavior disorder |
topic | Original Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857118/ https://www.ncbi.nlm.nih.gov/pubmed/34345972 http://dx.doi.org/10.1007/s00415-021-10728-x |
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