Lack of p62 Impairs Glycogen Aggregation and Exacerbates Pathology in a Mouse Model of Myoclonic Epilepsy of Lafora

Lafora disease (LD) is a fatal childhood-onset dementia characterized by the extensive accumulation of glycogen aggregates—the so-called Lafora Bodies (LBs)—in several organs. The accumulation of LBs in the brain underlies the neurological phenotype of the disease. LBs are composed of abnormal glyco...

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Detalles Bibliográficos
Autores principales: Pellegrini, Pasquale, Hervera, Arnau, Varea, Olga, Brewer, M. Kathryn, López-Soldado, Iliana, Guitart, Anna, Aguilera, Mònica, Prats, Neus, del Río, José Antonio, Guinovart, Joan J., Duran, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857170/
https://www.ncbi.nlm.nih.gov/pubmed/34962634
http://dx.doi.org/10.1007/s12035-021-02682-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857170/
https://www.ncbi.nlm.nih.gov/pubmed/34962634
http://dx.doi.org/10.1007/s12035-021-02682-6

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