Calibrated comparison of SARS-CoV-2 neutralizing antibody levels in response to protein-, mRNA-, and vector-based COVID-19 vaccines

SARS-CoV-2 neutralizing antibodies have been suggested to reflect the efficacy of COVID-19 vaccines. This study reports the direct comparison of the SARS-CoV-2 neutralizing antibody response elicited by a protein- (NVX-CoV2373), an mRNA- (Comirnaty), and a vector-based (Vaxzevria) COVID-19 vaccine,...

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Autores principales: Karbiener, Michael, Farcet, Maria R., Zollner, Andreas, Masuda, Taisei, Mori, Mitsuhiro, Moschen, Alexander R., Kreil, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857217/
https://www.ncbi.nlm.nih.gov/pubmed/35181655
http://dx.doi.org/10.1038/s41541-022-00455-3
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author Karbiener, Michael
Farcet, Maria R.
Zollner, Andreas
Masuda, Taisei
Mori, Mitsuhiro
Moschen, Alexander R.
Kreil, Thomas R.
author_facet Karbiener, Michael
Farcet, Maria R.
Zollner, Andreas
Masuda, Taisei
Mori, Mitsuhiro
Moschen, Alexander R.
Kreil, Thomas R.
author_sort Karbiener, Michael
collection PubMed
description SARS-CoV-2 neutralizing antibodies have been suggested to reflect the efficacy of COVID-19 vaccines. This study reports the direct comparison of the SARS-CoV-2 neutralizing antibody response elicited by a protein- (NVX-CoV2373), an mRNA- (Comirnaty), and a vector-based (Vaxzevria) COVID-19 vaccine, calibrated against the WHO international SARS-CoV-2 antibody standard, and further supports the use of neutralizing antibody levels as a correlate of protection.
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spelling pubmed-88572172022-03-03 Calibrated comparison of SARS-CoV-2 neutralizing antibody levels in response to protein-, mRNA-, and vector-based COVID-19 vaccines Karbiener, Michael Farcet, Maria R. Zollner, Andreas Masuda, Taisei Mori, Mitsuhiro Moschen, Alexander R. Kreil, Thomas R. NPJ Vaccines Brief Communication SARS-CoV-2 neutralizing antibodies have been suggested to reflect the efficacy of COVID-19 vaccines. This study reports the direct comparison of the SARS-CoV-2 neutralizing antibody response elicited by a protein- (NVX-CoV2373), an mRNA- (Comirnaty), and a vector-based (Vaxzevria) COVID-19 vaccine, calibrated against the WHO international SARS-CoV-2 antibody standard, and further supports the use of neutralizing antibody levels as a correlate of protection. Nature Publishing Group UK 2022-02-18 /pmc/articles/PMC8857217/ /pubmed/35181655 http://dx.doi.org/10.1038/s41541-022-00455-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Karbiener, Michael
Farcet, Maria R.
Zollner, Andreas
Masuda, Taisei
Mori, Mitsuhiro
Moschen, Alexander R.
Kreil, Thomas R.
Calibrated comparison of SARS-CoV-2 neutralizing antibody levels in response to protein-, mRNA-, and vector-based COVID-19 vaccines
title Calibrated comparison of SARS-CoV-2 neutralizing antibody levels in response to protein-, mRNA-, and vector-based COVID-19 vaccines
title_full Calibrated comparison of SARS-CoV-2 neutralizing antibody levels in response to protein-, mRNA-, and vector-based COVID-19 vaccines
title_fullStr Calibrated comparison of SARS-CoV-2 neutralizing antibody levels in response to protein-, mRNA-, and vector-based COVID-19 vaccines
title_full_unstemmed Calibrated comparison of SARS-CoV-2 neutralizing antibody levels in response to protein-, mRNA-, and vector-based COVID-19 vaccines
title_short Calibrated comparison of SARS-CoV-2 neutralizing antibody levels in response to protein-, mRNA-, and vector-based COVID-19 vaccines
title_sort calibrated comparison of sars-cov-2 neutralizing antibody levels in response to protein-, mrna-, and vector-based covid-19 vaccines
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857217/
https://www.ncbi.nlm.nih.gov/pubmed/35181655
http://dx.doi.org/10.1038/s41541-022-00455-3
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