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Identification of genomic signatures in bone marrow associated with clinical response of CD19 CAR T-cell therapy

CD19 CAR T-cell immunotherapy is a breakthrough treatment for B cell malignancies, but relapse and lack of response remain a challenge. The bone marrow microenvironment is a key factor in therapy resistance, however, little research has been reported concerning the relationship between transcriptomi...

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Detalles Bibliográficos
Autores principales: Shao, Lipei, Iyer, Avinash, Zhao, Yingdong, Somerville, Rob, Panch, Sandhya, Pelayo, Alejandra, Stroncek, David F., Jin, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857276/
https://www.ncbi.nlm.nih.gov/pubmed/35181722
http://dx.doi.org/10.1038/s41598-022-06830-3