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Identification of genomic signatures in bone marrow associated with clinical response of CD19 CAR T-cell therapy
CD19 CAR T-cell immunotherapy is a breakthrough treatment for B cell malignancies, but relapse and lack of response remain a challenge. The bone marrow microenvironment is a key factor in therapy resistance, however, little research has been reported concerning the relationship between transcriptomi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857276/ https://www.ncbi.nlm.nih.gov/pubmed/35181722 http://dx.doi.org/10.1038/s41598-022-06830-3 |