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Association between depression and anxiety on symptom and function after surgery for lumbar spinal stenosis

Evidence on the role of depression and anxiety in patients undergoing surgical treatment for symptomatic degenerative lumbar spinal stenosis (DLSS) is conflicting. We aimed to assess the association between depression and anxiety with symptoms and function in patients undergoing surgery for DLSS. In...

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Autores principales: Held, U., Burgstaller, J. M., Deforth, M., Steurer, J., Pichierri, G., Wertli, M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857319/
https://www.ncbi.nlm.nih.gov/pubmed/35181747
http://dx.doi.org/10.1038/s41598-022-06797-1
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author Held, U.
Burgstaller, J. M.
Deforth, M.
Steurer, J.
Pichierri, G.
Wertli, M. M.
author_facet Held, U.
Burgstaller, J. M.
Deforth, M.
Steurer, J.
Pichierri, G.
Wertli, M. M.
author_sort Held, U.
collection PubMed
description Evidence on the role of depression and anxiety in patients undergoing surgical treatment for symptomatic degenerative lumbar spinal stenosis (DLSS) is conflicting. We aimed to assess the association between depression and anxiety with symptoms and function in patients undergoing surgery for DLSS. Included were patients with symptomatic DLSS participating in a prospective multicentre cohort study who underwent surgery and completed the 24-month follow-up. We used the hospital anxiety and depression scale (HADS) to assess depression/anxiety. We used mixed-effects models to quantify the impact on the primary outcome change in the spinal stenosis measure (SSM) symptoms/function subscale from baseline to 12- and 24-months. Logistic regression analysis was used to quantify the odds of the SSM to reach a minimal clinically important difference (MCID) at 24 months follow-up. The robustness of the results in the presence of unmeasured confounding was quantified using a benchmarking method based on a multiple linear model. Out of 401 patients 72 (17.95%) were depressed and 80 anxious (19.05%). Depression was associated with more symptoms (β = 0.36, 95% confidence interval (CI) 0.20 to 0.51, p < 0.001) and worse function (β = 0.37, 95% CI 0.24 to 0.50, p < 0.001) at 12- and 24-months. Only the association between baseline depression and SSM symptoms/function was robust at 12 and 24 months. There was no evidence for baseline depression/anxiety decreasing odds for a MCID in SSM symptoms and function over time. In patients undergoing surgery for symptomatic DLSS, preoperative depression but not anxiety was associated with more severe symptoms and disability at 12 and 24 months.
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spelling pubmed-88573192022-02-22 Association between depression and anxiety on symptom and function after surgery for lumbar spinal stenosis Held, U. Burgstaller, J. M. Deforth, M. Steurer, J. Pichierri, G. Wertli, M. M. Sci Rep Article Evidence on the role of depression and anxiety in patients undergoing surgical treatment for symptomatic degenerative lumbar spinal stenosis (DLSS) is conflicting. We aimed to assess the association between depression and anxiety with symptoms and function in patients undergoing surgery for DLSS. Included were patients with symptomatic DLSS participating in a prospective multicentre cohort study who underwent surgery and completed the 24-month follow-up. We used the hospital anxiety and depression scale (HADS) to assess depression/anxiety. We used mixed-effects models to quantify the impact on the primary outcome change in the spinal stenosis measure (SSM) symptoms/function subscale from baseline to 12- and 24-months. Logistic regression analysis was used to quantify the odds of the SSM to reach a minimal clinically important difference (MCID) at 24 months follow-up. The robustness of the results in the presence of unmeasured confounding was quantified using a benchmarking method based on a multiple linear model. Out of 401 patients 72 (17.95%) were depressed and 80 anxious (19.05%). Depression was associated with more symptoms (β = 0.36, 95% confidence interval (CI) 0.20 to 0.51, p < 0.001) and worse function (β = 0.37, 95% CI 0.24 to 0.50, p < 0.001) at 12- and 24-months. Only the association between baseline depression and SSM symptoms/function was robust at 12 and 24 months. There was no evidence for baseline depression/anxiety decreasing odds for a MCID in SSM symptoms and function over time. In patients undergoing surgery for symptomatic DLSS, preoperative depression but not anxiety was associated with more severe symptoms and disability at 12 and 24 months. Nature Publishing Group UK 2022-02-18 /pmc/articles/PMC8857319/ /pubmed/35181747 http://dx.doi.org/10.1038/s41598-022-06797-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Held, U.
Burgstaller, J. M.
Deforth, M.
Steurer, J.
Pichierri, G.
Wertli, M. M.
Association between depression and anxiety on symptom and function after surgery for lumbar spinal stenosis
title Association between depression and anxiety on symptom and function after surgery for lumbar spinal stenosis
title_full Association between depression and anxiety on symptom and function after surgery for lumbar spinal stenosis
title_fullStr Association between depression and anxiety on symptom and function after surgery for lumbar spinal stenosis
title_full_unstemmed Association between depression and anxiety on symptom and function after surgery for lumbar spinal stenosis
title_short Association between depression and anxiety on symptom and function after surgery for lumbar spinal stenosis
title_sort association between depression and anxiety on symptom and function after surgery for lumbar spinal stenosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857319/
https://www.ncbi.nlm.nih.gov/pubmed/35181747
http://dx.doi.org/10.1038/s41598-022-06797-1
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