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Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD like pathology
Alzheimer's disease (AD) is a common neurodegenerative disorder. Aluminium chloride induces AD like pathology in rats. Renin angiotensin system plays a significant role in the pathogenesis and occurrence of Alzheimer's disease. In the present study we evaluated and compared the effect of C...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857426/ https://www.ncbi.nlm.nih.gov/pubmed/35243060 http://dx.doi.org/10.1016/j.heliyon.2022.e08935 |
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author | Mohapatra, Debashish Kanungo, Srikant Pradhan, Sweta Priyadarshini Jena, Susmita Prusty, Shakti Ketan Sahu, Pratap Kumar |
author_facet | Mohapatra, Debashish Kanungo, Srikant Pradhan, Sweta Priyadarshini Jena, Susmita Prusty, Shakti Ketan Sahu, Pratap Kumar |
author_sort | Mohapatra, Debashish |
collection | PubMed |
description | Alzheimer's disease (AD) is a common neurodegenerative disorder. Aluminium chloride induces AD like pathology in rats. Renin angiotensin system plays a significant role in the pathogenesis and occurrence of Alzheimer's disease. In the present study we evaluated and compared the effect of Captopril and Perindopril against aluminium chloride induced amyloidogenesis and cognitive dysfunction in rats. Wistar rats of both sex were divided randomly into four groups i.e. Group I was served as normal control and treated with normal saline, Group II was administered with AlCl(3) (100 mg/kg, p. o.) and Group III and IV received Captopril (30 mg/kg, p. o.) and Perindopril (5 mg/kg, p. o.) respectively 1hr prior to administration of AlCl(3). All the doses were given once daily for 42 days. The evaluation of memory function was carried out in Y-maze (spontaneous alternation), radial arm maze (number of correct responses) and elevated plus maze (transfer latency). After behavioral studies, estimation of antioxidant status (brain and serum), amyloid-β content (brain) and histopathology of brain hippocampus region was done. Administration of AlCl(3) for 42 days impaired cognitive dysfunction. Captopril and Perindopril prevented AlCl(3) induced cognitive dysfunction by improving spontaneous alternation behavior, number of correct responses and reducing transfer latency. They also increase the antioxidant status, reduce the Aβ42 content in the brain and reverse the histopathological changes caused by AlCl(3) in hippocampal region. Both Captopril and Perindopril protects against aluminium chloride induced amyloidogenesis and AD like pathology. Captopril is found to be more effective than Perindopril. |
format | Online Article Text |
id | pubmed-8857426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88574262022-03-02 Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD like pathology Mohapatra, Debashish Kanungo, Srikant Pradhan, Sweta Priyadarshini Jena, Susmita Prusty, Shakti Ketan Sahu, Pratap Kumar Heliyon Research Article Alzheimer's disease (AD) is a common neurodegenerative disorder. Aluminium chloride induces AD like pathology in rats. Renin angiotensin system plays a significant role in the pathogenesis and occurrence of Alzheimer's disease. In the present study we evaluated and compared the effect of Captopril and Perindopril against aluminium chloride induced amyloidogenesis and cognitive dysfunction in rats. Wistar rats of both sex were divided randomly into four groups i.e. Group I was served as normal control and treated with normal saline, Group II was administered with AlCl(3) (100 mg/kg, p. o.) and Group III and IV received Captopril (30 mg/kg, p. o.) and Perindopril (5 mg/kg, p. o.) respectively 1hr prior to administration of AlCl(3). All the doses were given once daily for 42 days. The evaluation of memory function was carried out in Y-maze (spontaneous alternation), radial arm maze (number of correct responses) and elevated plus maze (transfer latency). After behavioral studies, estimation of antioxidant status (brain and serum), amyloid-β content (brain) and histopathology of brain hippocampus region was done. Administration of AlCl(3) for 42 days impaired cognitive dysfunction. Captopril and Perindopril prevented AlCl(3) induced cognitive dysfunction by improving spontaneous alternation behavior, number of correct responses and reducing transfer latency. They also increase the antioxidant status, reduce the Aβ42 content in the brain and reverse the histopathological changes caused by AlCl(3) in hippocampal region. Both Captopril and Perindopril protects against aluminium chloride induced amyloidogenesis and AD like pathology. Captopril is found to be more effective than Perindopril. Elsevier 2022-02-11 /pmc/articles/PMC8857426/ /pubmed/35243060 http://dx.doi.org/10.1016/j.heliyon.2022.e08935 Text en © 2022 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Mohapatra, Debashish Kanungo, Srikant Pradhan, Sweta Priyadarshini Jena, Susmita Prusty, Shakti Ketan Sahu, Pratap Kumar Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD like pathology |
title | Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD like pathology |
title_full | Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD like pathology |
title_fullStr | Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD like pathology |
title_full_unstemmed | Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD like pathology |
title_short | Captopril is more effective than Perindopril against aluminium chloride induced amyloidogenesis and AD like pathology |
title_sort | captopril is more effective than perindopril against aluminium chloride induced amyloidogenesis and ad like pathology |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857426/ https://www.ncbi.nlm.nih.gov/pubmed/35243060 http://dx.doi.org/10.1016/j.heliyon.2022.e08935 |
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