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Molecular insights into the maturation of phosphodiesterase 6 by the specialized chaperone complex of HSP90 with AIPL1

Phosphodiesterase 6 (PDE6) is a key effector enzyme in vertebrate phototransduction, and its maturation and function are known to critically depend on a specialized chaperone, aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1). Defects in PDE6 and AIPL1 underlie several severe retinal dise...

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Detalles Bibliográficos
Autores principales: Yadav, Ravi P., Boyd, Kimberly, Artemyev, Nikolai O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857470/
https://www.ncbi.nlm.nih.gov/pubmed/35065964
http://dx.doi.org/10.1016/j.jbc.2022.101620