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Growth differentiation factor-11 downregulates steroidogenic acute regulatory protein expression through ALK5-mediated SMAD3 signaling pathway in human granulosa-lutein cells

BACKGROUND: Growth differentiation factor-11 (GDF-11) belongs to the transforming growth factor-β (TGF-β) superfamily. To date, the expression of GDF-11 in the ovary and its role in regulating ovarian function are completely unknown. Ovarian granulosa cell-mediated steroidogenesis plays a pivotal ro...

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Detalles Bibliográficos
Autores principales:	Jia, Qiongqiong, Liu, Boqun, Dang, Xuan, Guo, Yanjie, Han, Xiaoyu, Song, Tinglin, Cheng, Jung-Chien, Fang, Lanlan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857810/ https://www.ncbi.nlm.nih.gov/pubmed/35183204 http://dx.doi.org/10.1186/s12958-022-00912-7

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