IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET)

BACKGROUND: Few new drugs have been developed for chronic pain. Drug development is challenged by uncertainty about whether the drug engages the human target sufficiently to have a meaningful pharmacodynamic effect. IMI2-PainCare-BioPain-RCT1 is one of four similarly designed studies that aim to lin...

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Detalles Bibliográficos
Autores principales: Nochi, Zahra, Pia, Hossein, Bloms-Funke, Petra, Boesl, Irmgard, Caspani, Ombretta, Chapman, Sonya C., Fardo, Francesca, Genser, Bernd, Goetz, Marcus, Kostenko, Anna V., Leone, Caterina, Li, Thomas, Mouraux, André, Pelz, Bernhard, Pogatzki-Zahn, Esther, Schilder, Andreas, Schnetter, Erik, Schubart, Karin, Stouffs, Alexandre, Tracey, Irene, Troconiz, Iñaki F., Truini, Andrea, Van Niel, Johannes, Vela, Jose Miguel, Vincent, Katy, Vollert, Jan, Wanigasekera, Vishvarani, Wittayer, Matthias, Tankisi, Hatice, Finnerup, Nanna B., Phillips, Keith G., Treede, Rolf-Detlef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857873/
https://www.ncbi.nlm.nih.gov/pubmed/35183242
http://dx.doi.org/10.1186/s13063-022-06087-1

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