Effects of Hemodialysis on Intraocular Pressure and Ocular Biological Parameters in Different Angle Structures

PURPOSE: This study is aimed at evaluating the effects of hemodialysis on intraocular pressure (IOP) and exploring the possible factors affecting IOP. METHODS: Fifty-two patients with hemodialysis (HD) that were diagnosed with chronic renal failure by nephrology were divided into four groups: wide angle, narrow angle, extremely narrow angle, and closed angle. IOP, central anterior chamber depth (ACD), lens thickness (LT), angle opening distance (AOD), trabecular-iris angle (TIA), iris thickness (IT), and ciliary body thickness (CBT) were recorded before and after HD. The Pearson coefficient test was used to determine correlations among changes in IOP and AOD, ACD, TIA, IT, CBT, and LT. RESULTS: The IOP in the extremely narrow angle group had significant difference compared with that in the wide angle group and narrow angle group (P < 0.05, P < 0.01). In the narrow angle group, change in LT was positively correlated with change in IOP (P < 0.05). In the extremely narrow angle group, change in LT was positively correlated with change in IOP (P<0.01), whereas changes in AOD and TIA were negatively correlated with change in IOP (P < 0.01; P < 0.05). CONCLUSION: The effect of HD on IOP varies with the structure of the anterior chamber. The increasing of IOP in the extremely narrow-angle group is related with the changes of structure of anterior chamber.