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Research Progress on the Pharmacological Action of Schisantherin A
Schisantherin A (Sch A) is a dibenzocyclooctadiene lignan monomer isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (S. chinensis). At present, many studies have shown that Sch A has a wide range of pharmacological effects, including its anti-Parkinson and anti-inflammatory effects and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858060/ https://www.ncbi.nlm.nih.gov/pubmed/35190748 http://dx.doi.org/10.1155/2022/6420865 |
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author | Xiao, Zehao Xiao, Wen Li, Guilin |
author_facet | Xiao, Zehao Xiao, Wen Li, Guilin |
author_sort | Xiao, Zehao |
collection | PubMed |
description | Schisantherin A (Sch A) is a dibenzocyclooctadiene lignan monomer isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (S. chinensis). At present, many studies have shown that Sch A has a wide range of pharmacological effects, including its anti-Parkinson and anti-inflammatory effects and ability to protect the liver, protect against ischemia-reperfusion (I/R) injury, suppress osteoclast formation, and improve learning and memory. Its mechanism may be related to the antioxidant, anti-inflammatory, and antiapoptotic properties of Sch A through the MAPK, NF-κB, AKT/GSK3β, and PI3K/AKT pathways. This is the first review of the recent studies on the pharmacological mechanism of Sch A. |
format | Online Article Text |
id | pubmed-8858060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-88580602022-02-20 Research Progress on the Pharmacological Action of Schisantherin A Xiao, Zehao Xiao, Wen Li, Guilin Evid Based Complement Alternat Med Review Article Schisantherin A (Sch A) is a dibenzocyclooctadiene lignan monomer isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (S. chinensis). At present, many studies have shown that Sch A has a wide range of pharmacological effects, including its anti-Parkinson and anti-inflammatory effects and ability to protect the liver, protect against ischemia-reperfusion (I/R) injury, suppress osteoclast formation, and improve learning and memory. Its mechanism may be related to the antioxidant, anti-inflammatory, and antiapoptotic properties of Sch A through the MAPK, NF-κB, AKT/GSK3β, and PI3K/AKT pathways. This is the first review of the recent studies on the pharmacological mechanism of Sch A. Hindawi 2022-02-12 /pmc/articles/PMC8858060/ /pubmed/35190748 http://dx.doi.org/10.1155/2022/6420865 Text en Copyright © 2022 Zehao Xiao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Xiao, Zehao Xiao, Wen Li, Guilin Research Progress on the Pharmacological Action of Schisantherin A |
title | Research Progress on the Pharmacological Action of Schisantherin A |
title_full | Research Progress on the Pharmacological Action of Schisantherin A |
title_fullStr | Research Progress on the Pharmacological Action of Schisantherin A |
title_full_unstemmed | Research Progress on the Pharmacological Action of Schisantherin A |
title_short | Research Progress on the Pharmacological Action of Schisantherin A |
title_sort | research progress on the pharmacological action of schisantherin a |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858060/ https://www.ncbi.nlm.nih.gov/pubmed/35190748 http://dx.doi.org/10.1155/2022/6420865 |
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