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Research Progress on the Pharmacological Action of Schisantherin A

Schisantherin A (Sch A) is a dibenzocyclooctadiene lignan monomer isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (S. chinensis). At present, many studies have shown that Sch A has a wide range of pharmacological effects, including its anti-Parkinson and anti-inflammatory effects and...

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Detalles Bibliográficos
Autores principales: Xiao, Zehao, Xiao, Wen, Li, Guilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858060/
https://www.ncbi.nlm.nih.gov/pubmed/35190748
http://dx.doi.org/10.1155/2022/6420865
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author Xiao, Zehao
Xiao, Wen
Li, Guilin
author_facet Xiao, Zehao
Xiao, Wen
Li, Guilin
author_sort Xiao, Zehao
collection PubMed
description Schisantherin A (Sch A) is a dibenzocyclooctadiene lignan monomer isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (S. chinensis). At present, many studies have shown that Sch A has a wide range of pharmacological effects, including its anti-Parkinson and anti-inflammatory effects and ability to protect the liver, protect against ischemia-reperfusion (I/R) injury, suppress osteoclast formation, and improve learning and memory. Its mechanism may be related to the antioxidant, anti-inflammatory, and antiapoptotic properties of Sch A through the MAPK, NF-κB, AKT/GSK3β, and PI3K/AKT pathways. This is the first review of the recent studies on the pharmacological mechanism of Sch A.
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spelling pubmed-88580602022-02-20 Research Progress on the Pharmacological Action of Schisantherin A Xiao, Zehao Xiao, Wen Li, Guilin Evid Based Complement Alternat Med Review Article Schisantherin A (Sch A) is a dibenzocyclooctadiene lignan monomer isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (S. chinensis). At present, many studies have shown that Sch A has a wide range of pharmacological effects, including its anti-Parkinson and anti-inflammatory effects and ability to protect the liver, protect against ischemia-reperfusion (I/R) injury, suppress osteoclast formation, and improve learning and memory. Its mechanism may be related to the antioxidant, anti-inflammatory, and antiapoptotic properties of Sch A through the MAPK, NF-κB, AKT/GSK3β, and PI3K/AKT pathways. This is the first review of the recent studies on the pharmacological mechanism of Sch A. Hindawi 2022-02-12 /pmc/articles/PMC8858060/ /pubmed/35190748 http://dx.doi.org/10.1155/2022/6420865 Text en Copyright © 2022 Zehao Xiao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xiao, Zehao
Xiao, Wen
Li, Guilin
Research Progress on the Pharmacological Action of Schisantherin A
title Research Progress on the Pharmacological Action of Schisantherin A
title_full Research Progress on the Pharmacological Action of Schisantherin A
title_fullStr Research Progress on the Pharmacological Action of Schisantherin A
title_full_unstemmed Research Progress on the Pharmacological Action of Schisantherin A
title_short Research Progress on the Pharmacological Action of Schisantherin A
title_sort research progress on the pharmacological action of schisantherin a
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858060/
https://www.ncbi.nlm.nih.gov/pubmed/35190748
http://dx.doi.org/10.1155/2022/6420865
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