CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587

Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor. E3 ligases play important functions in glioma pathogenesis. CRISPR system offers a powerful platform for genome manipulation, while the screen of E3 ligases in GBM still remains to be explored. Here, we first constru...

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Detalles Bibliográficos
Autores principales: Lin, Kun, Shen, Shang-Hang, Lu, Feng, Zheng, Pengfeng, Wu, Shizhong, Liao, Jingwei, Jiang, Xiaohang, Zeng, Guangming, Wei, De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858481/
https://www.ncbi.nlm.nih.gov/pubmed/35183197
http://dx.doi.org/10.1186/s12967-022-03284-z

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