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Effect of interaction between occupational stress and polymorphisms of MTHFR gene and SELE gene on hypertension

BACKGROUND: Gene-environment interaction is related to the prevalence of hypertension, but the impact of genetic polymorphisms on hypertension may vary due to different geography and population. OBJECTIVE: To explore the impact of the interaction among occupational stress and MTHFR gene and SELE gen...

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Autores principales: Yang, Fen, Qiu, Ruiying, Abudoubari, Saimaitikari, Tao, Ning, An, Hengqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858580/
https://www.ncbi.nlm.nih.gov/pubmed/35194526
http://dx.doi.org/10.7717/peerj.12914
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author Yang, Fen
Qiu, Ruiying
Abudoubari, Saimaitikari
Tao, Ning
An, Hengqing
author_facet Yang, Fen
Qiu, Ruiying
Abudoubari, Saimaitikari
Tao, Ning
An, Hengqing
author_sort Yang, Fen
collection PubMed
description BACKGROUND: Gene-environment interaction is related to the prevalence of hypertension, but the impact of genetic polymorphisms on hypertension may vary due to different geography and population. OBJECTIVE: To explore the impact of the interaction among occupational stress and MTHFR gene and SELE gene polymorphism on the prevalence of hypertension in Xinjiang oil workers. METHODS: A case-control study was conducted on 310 oil workers. In an oilfield base in Karamay City, Xinjiang, 155 hypertensive patients aged 18~60 years old with more than one year of service were selected as the case group, and 155 oil workers without hypertension were selected as the control group according to the 1:1 matching principle (matching conditions: the gender and shift were the same. The age is around 2 years old). The Occupational Stress Scale was used to evaluate the degree of occupational stress, PCR technique was used to detect MTHFR and SELE gene polymorphism, Logistic regression analysis was used to analyze the effects of gene and occupational stress on hypertension, and gene-gene and gene-environment interactions were analyzed by generalized multi-factor dimension reduction method. RESULTS: The G98T polymorphism of SELE gene (χ(2) = 6.776, P = 0.034), the C677T (χ(2) = 7.130, P = 0.028) and A1298C (χ(2) = 12.036, P = 0.002) loci of MTHFR gene and the degree of occupational stress (χ(2) = 11.921, P = 0.003) were significantly different between the case group and the control group. The genotypes GT at the G98T polymorphism of the SELE gene (OR = 2.151, 95% CI [1.227–3.375]), and the dominant model (AC/CC vs AA, OR = 1.925, 95% CI [1.613–3.816]); AC and CC at the A1298C polymorphism of the MTHFR gene (OR(AC) = 1.917, 95% CI [1.064–3.453]; OR(CC) = 2.233, 95% CI [1.082–4.609]), the additive model (CC vs AA, OR = 2.497, 95% CI [1.277–4.883]) and the dominant model (AC/CC vs AA, OR = 2.012, 95% CI [1.200–3.373]); at the C677T polymorphism of the MTHFR gene CT and TT (OR(CT) = 1.913, 95% CI [1.085–3.375]; OR(TT) = 3.117, 95% CI [1.430–6.795]), the additive model (CC vs AA, OR = 1.913, 95% CI [1.085–3.375]) and the dominant model (AC/CC vs AA, OR = 2.012, 95% CI [1.200–3.373]), which could increase hypertension risk (P < 0.05). The gene-gene interaction showed that there was a positive interaction between the A1298C and C677T sites of the MTHFR gene, and the gene-occupational stress interaction showed that there was a positive interaction between the A1298C and C677T sites of the MTHFR gene and the occupational stress. CONCLUSION: The interaction of gene mutation and occupational stress in Xinjiang oil workers maybe increase the risk of hypertension.
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spelling pubmed-88585802022-02-21 Effect of interaction between occupational stress and polymorphisms of MTHFR gene and SELE gene on hypertension Yang, Fen Qiu, Ruiying Abudoubari, Saimaitikari Tao, Ning An, Hengqing PeerJ Epidemiology BACKGROUND: Gene-environment interaction is related to the prevalence of hypertension, but the impact of genetic polymorphisms on hypertension may vary due to different geography and population. OBJECTIVE: To explore the impact of the interaction among occupational stress and MTHFR gene and SELE gene polymorphism on the prevalence of hypertension in Xinjiang oil workers. METHODS: A case-control study was conducted on 310 oil workers. In an oilfield base in Karamay City, Xinjiang, 155 hypertensive patients aged 18~60 years old with more than one year of service were selected as the case group, and 155 oil workers without hypertension were selected as the control group according to the 1:1 matching principle (matching conditions: the gender and shift were the same. The age is around 2 years old). The Occupational Stress Scale was used to evaluate the degree of occupational stress, PCR technique was used to detect MTHFR and SELE gene polymorphism, Logistic regression analysis was used to analyze the effects of gene and occupational stress on hypertension, and gene-gene and gene-environment interactions were analyzed by generalized multi-factor dimension reduction method. RESULTS: The G98T polymorphism of SELE gene (χ(2) = 6.776, P = 0.034), the C677T (χ(2) = 7.130, P = 0.028) and A1298C (χ(2) = 12.036, P = 0.002) loci of MTHFR gene and the degree of occupational stress (χ(2) = 11.921, P = 0.003) were significantly different between the case group and the control group. The genotypes GT at the G98T polymorphism of the SELE gene (OR = 2.151, 95% CI [1.227–3.375]), and the dominant model (AC/CC vs AA, OR = 1.925, 95% CI [1.613–3.816]); AC and CC at the A1298C polymorphism of the MTHFR gene (OR(AC) = 1.917, 95% CI [1.064–3.453]; OR(CC) = 2.233, 95% CI [1.082–4.609]), the additive model (CC vs AA, OR = 2.497, 95% CI [1.277–4.883]) and the dominant model (AC/CC vs AA, OR = 2.012, 95% CI [1.200–3.373]); at the C677T polymorphism of the MTHFR gene CT and TT (OR(CT) = 1.913, 95% CI [1.085–3.375]; OR(TT) = 3.117, 95% CI [1.430–6.795]), the additive model (CC vs AA, OR = 1.913, 95% CI [1.085–3.375]) and the dominant model (AC/CC vs AA, OR = 2.012, 95% CI [1.200–3.373]), which could increase hypertension risk (P < 0.05). The gene-gene interaction showed that there was a positive interaction between the A1298C and C677T sites of the MTHFR gene, and the gene-occupational stress interaction showed that there was a positive interaction between the A1298C and C677T sites of the MTHFR gene and the occupational stress. CONCLUSION: The interaction of gene mutation and occupational stress in Xinjiang oil workers maybe increase the risk of hypertension. PeerJ Inc. 2022-02-16 /pmc/articles/PMC8858580/ /pubmed/35194526 http://dx.doi.org/10.7717/peerj.12914 Text en © 2022 Yang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Epidemiology
Yang, Fen
Qiu, Ruiying
Abudoubari, Saimaitikari
Tao, Ning
An, Hengqing
Effect of interaction between occupational stress and polymorphisms of MTHFR gene and SELE gene on hypertension
title Effect of interaction between occupational stress and polymorphisms of MTHFR gene and SELE gene on hypertension
title_full Effect of interaction between occupational stress and polymorphisms of MTHFR gene and SELE gene on hypertension
title_fullStr Effect of interaction between occupational stress and polymorphisms of MTHFR gene and SELE gene on hypertension
title_full_unstemmed Effect of interaction between occupational stress and polymorphisms of MTHFR gene and SELE gene on hypertension
title_short Effect of interaction between occupational stress and polymorphisms of MTHFR gene and SELE gene on hypertension
title_sort effect of interaction between occupational stress and polymorphisms of mthfr gene and sele gene on hypertension
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858580/
https://www.ncbi.nlm.nih.gov/pubmed/35194526
http://dx.doi.org/10.7717/peerj.12914
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