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Limited extent and consequences of pancreatic SARS-CoV-2 infection
Concerns that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), may cause new-onset diabetes persist in an evolving research landscape, and precise risk assessment is hampered by, at times, conflicting evidence....
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s).
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858708/ https://www.ncbi.nlm.nih.gov/pubmed/35247306 http://dx.doi.org/10.1016/j.celrep.2022.110508 |
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author | van der Heide, Verena Jangra, Sonia Cohen, Phillip Rathnasinghe, Raveen Aslam, Sadaf Aydillo, Teresa Geanon, Daniel Handler, Diana Kelley, Geoffrey Lee, Brian Rahman, Adeeb Dawson, Travis Qi, Jingjing D'Souza, Darwin Kim-Schulze, Seunghee Panzer, Julia K. Caicedo, Alejandro Kusmartseva, Irina Posgai, Amanda L. Atkinson, Mark A. Albrecht, Randy A. García-Sastre, Adolfo Rosenberg, Brad R. Schotsaert, Michael Homann, Dirk |
author_facet | van der Heide, Verena Jangra, Sonia Cohen, Phillip Rathnasinghe, Raveen Aslam, Sadaf Aydillo, Teresa Geanon, Daniel Handler, Diana Kelley, Geoffrey Lee, Brian Rahman, Adeeb Dawson, Travis Qi, Jingjing D'Souza, Darwin Kim-Schulze, Seunghee Panzer, Julia K. Caicedo, Alejandro Kusmartseva, Irina Posgai, Amanda L. Atkinson, Mark A. Albrecht, Randy A. García-Sastre, Adolfo Rosenberg, Brad R. Schotsaert, Michael Homann, Dirk |
author_sort | van der Heide, Verena |
collection | PubMed |
description | Concerns that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), may cause new-onset diabetes persist in an evolving research landscape, and precise risk assessment is hampered by, at times, conflicting evidence. Here, leveraging comprehensive single-cell analyses of in vitro SARS-CoV-2-infected human pancreatic islets, we demonstrate that productive infection is strictly dependent on the SARS-CoV-2 entry receptor ACE2 and targets practically all pancreatic cell types. Importantly, the infection remains highly circumscribed and largely non-cytopathic and, despite a high viral burden in infected subsets, promotes only modest cellular perturbations and inflammatory responses. Similar experimental outcomes are also observed after islet infection with endemic coronaviruses. Thus, the limits of pancreatic SARS-CoV-2 infection, even under in vitro conditions of enhanced virus exposure, challenge the proposition that in vivo targeting of β cells by SARS-CoV-2 precipitates new-onset diabetes. Whether restricted pancreatic damage and immunological alterations accrued by COVID-19 increase cumulative diabetes risk, however, remains to be evaluated. |
format | Online Article Text |
id | pubmed-8858708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Author(s). |
record_format | MEDLINE/PubMed |
spelling | pubmed-88587082022-02-22 Limited extent and consequences of pancreatic SARS-CoV-2 infection van der Heide, Verena Jangra, Sonia Cohen, Phillip Rathnasinghe, Raveen Aslam, Sadaf Aydillo, Teresa Geanon, Daniel Handler, Diana Kelley, Geoffrey Lee, Brian Rahman, Adeeb Dawson, Travis Qi, Jingjing D'Souza, Darwin Kim-Schulze, Seunghee Panzer, Julia K. Caicedo, Alejandro Kusmartseva, Irina Posgai, Amanda L. Atkinson, Mark A. Albrecht, Randy A. García-Sastre, Adolfo Rosenberg, Brad R. Schotsaert, Michael Homann, Dirk Cell Rep Article Concerns that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), may cause new-onset diabetes persist in an evolving research landscape, and precise risk assessment is hampered by, at times, conflicting evidence. Here, leveraging comprehensive single-cell analyses of in vitro SARS-CoV-2-infected human pancreatic islets, we demonstrate that productive infection is strictly dependent on the SARS-CoV-2 entry receptor ACE2 and targets practically all pancreatic cell types. Importantly, the infection remains highly circumscribed and largely non-cytopathic and, despite a high viral burden in infected subsets, promotes only modest cellular perturbations and inflammatory responses. Similar experimental outcomes are also observed after islet infection with endemic coronaviruses. Thus, the limits of pancreatic SARS-CoV-2 infection, even under in vitro conditions of enhanced virus exposure, challenge the proposition that in vivo targeting of β cells by SARS-CoV-2 precipitates new-onset diabetes. Whether restricted pancreatic damage and immunological alterations accrued by COVID-19 increase cumulative diabetes risk, however, remains to be evaluated. The Author(s). 2022-03-15 2022-02-21 /pmc/articles/PMC8858708/ /pubmed/35247306 http://dx.doi.org/10.1016/j.celrep.2022.110508 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article van der Heide, Verena Jangra, Sonia Cohen, Phillip Rathnasinghe, Raveen Aslam, Sadaf Aydillo, Teresa Geanon, Daniel Handler, Diana Kelley, Geoffrey Lee, Brian Rahman, Adeeb Dawson, Travis Qi, Jingjing D'Souza, Darwin Kim-Schulze, Seunghee Panzer, Julia K. Caicedo, Alejandro Kusmartseva, Irina Posgai, Amanda L. Atkinson, Mark A. Albrecht, Randy A. García-Sastre, Adolfo Rosenberg, Brad R. Schotsaert, Michael Homann, Dirk Limited extent and consequences of pancreatic SARS-CoV-2 infection |
title | Limited extent and consequences of pancreatic SARS-CoV-2 infection |
title_full | Limited extent and consequences of pancreatic SARS-CoV-2 infection |
title_fullStr | Limited extent and consequences of pancreatic SARS-CoV-2 infection |
title_full_unstemmed | Limited extent and consequences of pancreatic SARS-CoV-2 infection |
title_short | Limited extent and consequences of pancreatic SARS-CoV-2 infection |
title_sort | limited extent and consequences of pancreatic sars-cov-2 infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858708/ https://www.ncbi.nlm.nih.gov/pubmed/35247306 http://dx.doi.org/10.1016/j.celrep.2022.110508 |
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