Cargando…

BCG vaccination provides protection against IAV but not SARS-CoV-2

Since the vast majority of species solely rely on innate immunity for host defense, it stands to reason that a critical evolutionary trait like immunological memory evolved in this primitive branch of our immune system. There is ample evidence that vaccines such as bacillus Calmette-Guérin (BCG) ind...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaufmann, Eva, Khan, Nargis, Tran, Kim A., Ulndreaj, Antigona, Pernet, Erwan, Fontes, Ghislaine, Lupien, Andréanne, Desmeules, Patrice, McIntosh, Fiona, Abow, Amina, Moorlag, Simone J.C.F.M., Debisarun, Priya, Mossman, Karen, Banerjee, Arinjay, Karo-Atar, Danielle, Sadeghi, Mina, Mubareka, Samira, Vinh, Donald C., King, Irah L., Robbins, Clinton S., Behr, Marcel A., Netea, Mihai G., Joubert, Philippe, Divangahi, Maziar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858710/
https://www.ncbi.nlm.nih.gov/pubmed/35235831
http://dx.doi.org/10.1016/j.celrep.2022.110502
Descripción
Sumario:Since the vast majority of species solely rely on innate immunity for host defense, it stands to reason that a critical evolutionary trait like immunological memory evolved in this primitive branch of our immune system. There is ample evidence that vaccines such as bacillus Calmette-Guérin (BCG) induce protective innate immune memory responses (trained immunity) against heterologous pathogens. Here we show that while BCG vaccination significantly reduces morbidity and mortality against influenza A virus (IAV), it fails to provide protection against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In contrast to IAV, SARS-CoV-2 infection leads to unique pulmonary vasculature damage facilitating viral dissemination to other organs, including the bone marrow (BM), a central site for BCG-mediated trained immunity. Finally, monocytes from BCG-vaccinated individuals mount an efficient cytokine response to IAV infection, while this response is minimal following SARS-CoV-2. Collectively, our data suggest that the protective capacity of BCG vaccination is contingent on viral pathogenesis and tissue tropism.