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Cognitive Impairment in Heart Failure: Landscape, Challenges, and Future Directions
Heart failure (HF) is a major global healthcare problem accounting for substantial deterioration of prognosis. As a complex clinical syndrome, HF often coexists with multi-comorbidities of which cognitive impairment (CI) is particularly important. CI is increasing in prevalence among patients with H...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858826/ https://www.ncbi.nlm.nih.gov/pubmed/35198608 http://dx.doi.org/10.3389/fcvm.2021.831734 |
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author | Yang, Mengxi Sun, Di Wang, Yu Yan, Mengwen Zheng, Jingang Ren, Jingyi |
author_facet | Yang, Mengxi Sun, Di Wang, Yu Yan, Mengwen Zheng, Jingang Ren, Jingyi |
author_sort | Yang, Mengxi |
collection | PubMed |
description | Heart failure (HF) is a major global healthcare problem accounting for substantial deterioration of prognosis. As a complex clinical syndrome, HF often coexists with multi-comorbidities of which cognitive impairment (CI) is particularly important. CI is increasing in prevalence among patients with HF and is present in around 40%, even up to 60%, of elderly patients with HF. As a potent and independent prognostic factor, CI significantly increases the hospitalization and mortality and decreases quality of life in patients with HF. There has been a growing awareness of the complex bidirectional interaction between HF and CI as it shares a number of common pathophysiological pathways including reduced cerebral blood flow, inflammation, and neurohumoral activations. Research that focus on the precise mechanism for CI in HF is still ever insufficient. As the tremendous adverse consequences of CI in HF, effective early diagnosis of CI in HF and interventions for these patients may halt disease progression and improve prognosis. The current clinical guidelines in HF have begun to emphasize the importance of CI. However, nearly half of CI in HF is underdiagnosed, and few recommendations are available to guide clinicians about how to approach CI in patients with HF. This review aims to synthesize knowledge about the link between HF and cognitive dysfunction, issues pertaining to screening, diagnosis and management of CI in patients with HF, and emerging therapies for prevention. Based on data from current studies, critical gaps in knowledge of CI in HF are identified, and future research directions to guide the field forward are proposed. |
format | Online Article Text |
id | pubmed-8858826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88588262022-02-22 Cognitive Impairment in Heart Failure: Landscape, Challenges, and Future Directions Yang, Mengxi Sun, Di Wang, Yu Yan, Mengwen Zheng, Jingang Ren, Jingyi Front Cardiovasc Med Cardiovascular Medicine Heart failure (HF) is a major global healthcare problem accounting for substantial deterioration of prognosis. As a complex clinical syndrome, HF often coexists with multi-comorbidities of which cognitive impairment (CI) is particularly important. CI is increasing in prevalence among patients with HF and is present in around 40%, even up to 60%, of elderly patients with HF. As a potent and independent prognostic factor, CI significantly increases the hospitalization and mortality and decreases quality of life in patients with HF. There has been a growing awareness of the complex bidirectional interaction between HF and CI as it shares a number of common pathophysiological pathways including reduced cerebral blood flow, inflammation, and neurohumoral activations. Research that focus on the precise mechanism for CI in HF is still ever insufficient. As the tremendous adverse consequences of CI in HF, effective early diagnosis of CI in HF and interventions for these patients may halt disease progression and improve prognosis. The current clinical guidelines in HF have begun to emphasize the importance of CI. However, nearly half of CI in HF is underdiagnosed, and few recommendations are available to guide clinicians about how to approach CI in patients with HF. This review aims to synthesize knowledge about the link between HF and cognitive dysfunction, issues pertaining to screening, diagnosis and management of CI in patients with HF, and emerging therapies for prevention. Based on data from current studies, critical gaps in knowledge of CI in HF are identified, and future research directions to guide the field forward are proposed. Frontiers Media S.A. 2022-02-07 /pmc/articles/PMC8858826/ /pubmed/35198608 http://dx.doi.org/10.3389/fcvm.2021.831734 Text en Copyright © 2022 Yang, Sun, Wang, Yan, Zheng and Ren. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Yang, Mengxi Sun, Di Wang, Yu Yan, Mengwen Zheng, Jingang Ren, Jingyi Cognitive Impairment in Heart Failure: Landscape, Challenges, and Future Directions |
title | Cognitive Impairment in Heart Failure: Landscape, Challenges, and Future Directions |
title_full | Cognitive Impairment in Heart Failure: Landscape, Challenges, and Future Directions |
title_fullStr | Cognitive Impairment in Heart Failure: Landscape, Challenges, and Future Directions |
title_full_unstemmed | Cognitive Impairment in Heart Failure: Landscape, Challenges, and Future Directions |
title_short | Cognitive Impairment in Heart Failure: Landscape, Challenges, and Future Directions |
title_sort | cognitive impairment in heart failure: landscape, challenges, and future directions |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858826/ https://www.ncbi.nlm.nih.gov/pubmed/35198608 http://dx.doi.org/10.3389/fcvm.2021.831734 |
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