Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence

Mesenchymal stem cell (MSC) transplantation has been widely used as a potential treatment for a variety of diseases. However, the contradiction between the low survival rate of transplanted cells and the beneficial therapeutic effects has affected its clinical use. Lysosomes as organelles at the cen...

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Autores principales: Zhang, Weijun, Bai, Jinwu, Hang, Kai, Xu, Jianxiang, Zhou, Chengwei, Li, Lijun, Wang, Zhongxiang, Wang, Yibo, Wang, Kanbin, Xue, Deting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858834/
https://www.ncbi.nlm.nih.gov/pubmed/35198560
http://dx.doi.org/10.3389/fcell.2022.817877
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author Zhang, Weijun
Bai, Jinwu
Hang, Kai
Xu, Jianxiang
Zhou, Chengwei
Li, Lijun
Wang, Zhongxiang
Wang, Yibo
Wang, Kanbin
Xue, Deting
author_facet Zhang, Weijun
Bai, Jinwu
Hang, Kai
Xu, Jianxiang
Zhou, Chengwei
Li, Lijun
Wang, Zhongxiang
Wang, Yibo
Wang, Kanbin
Xue, Deting
author_sort Zhang, Weijun
collection PubMed
description Mesenchymal stem cell (MSC) transplantation has been widely used as a potential treatment for a variety of diseases. However, the contradiction between the low survival rate of transplanted cells and the beneficial therapeutic effects has affected its clinical use. Lysosomes as organelles at the center of cellular recycling and metabolic signaling, play essential roles in MSC homeostasis. In the first part of this review, we summarize the role of lysosomal acidification dysfunction in MSC senescence. In the second part, we summarize some of the potential strategies targeting lysosomal proteins to enhance the therapeutic effect of MSCs.
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spelling pubmed-88588342022-02-22 Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence Zhang, Weijun Bai, Jinwu Hang, Kai Xu, Jianxiang Zhou, Chengwei Li, Lijun Wang, Zhongxiang Wang, Yibo Wang, Kanbin Xue, Deting Front Cell Dev Biol Cell and Developmental Biology Mesenchymal stem cell (MSC) transplantation has been widely used as a potential treatment for a variety of diseases. However, the contradiction between the low survival rate of transplanted cells and the beneficial therapeutic effects has affected its clinical use. Lysosomes as organelles at the center of cellular recycling and metabolic signaling, play essential roles in MSC homeostasis. In the first part of this review, we summarize the role of lysosomal acidification dysfunction in MSC senescence. In the second part, we summarize some of the potential strategies targeting lysosomal proteins to enhance the therapeutic effect of MSCs. Frontiers Media S.A. 2022-02-07 /pmc/articles/PMC8858834/ /pubmed/35198560 http://dx.doi.org/10.3389/fcell.2022.817877 Text en Copyright © 2022 Zhang, Bai, Hang, Xu, Zhou, Li, Wang, Wang, Wang and Xue. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhang, Weijun
Bai, Jinwu
Hang, Kai
Xu, Jianxiang
Zhou, Chengwei
Li, Lijun
Wang, Zhongxiang
Wang, Yibo
Wang, Kanbin
Xue, Deting
Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence
title Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence
title_full Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence
title_fullStr Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence
title_full_unstemmed Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence
title_short Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence
title_sort role of lysosomal acidification dysfunction in mesenchymal stem cell senescence
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858834/
https://www.ncbi.nlm.nih.gov/pubmed/35198560
http://dx.doi.org/10.3389/fcell.2022.817877
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