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Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview
The adipose organ comprises two main fat depots termed white and brown adipose tissues. Adipogenesis is a process leading to newly differentiated adipocytes starting from precursor cells, which requires the contribution of many cellular activities at the genome, transcriptome, proteome, and metabolo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858922/ https://www.ncbi.nlm.nih.gov/pubmed/35184223 http://dx.doi.org/10.1007/s00018-022-04169-6 |
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author | Audano, M. Pedretti, S. Caruso, D. Crestani, M. De Fabiani, E. Mitro, N. |
author_facet | Audano, M. Pedretti, S. Caruso, D. Crestani, M. De Fabiani, E. Mitro, N. |
author_sort | Audano, M. |
collection | PubMed |
description | The adipose organ comprises two main fat depots termed white and brown adipose tissues. Adipogenesis is a process leading to newly differentiated adipocytes starting from precursor cells, which requires the contribution of many cellular activities at the genome, transcriptome, proteome, and metabolome levels. The adipogenic program is accomplished through two sequential phases; the first includes events favoring the commitment of adipose tissue stem cells/precursors to preadipocytes, while the second involves mechanisms that allow the achievement of full adipocyte differentiation. While there is a very large literature about the mechanisms involved in terminal adipogenesis, little is known about the first stage of this process. Growing interest in this field is due to the recent identification of adipose tissue precursors, which include a heterogenous cell population within different types of adipose tissue as well as within the same fat depot. In addition, the alteration of the heterogeneity of adipose tissue stem cells and of the mechanisms involved in their commitment have been linked to adipose tissue development defects and hence to the onset/progression of metabolic diseases, such as obesity. For this reason, the characterization of early adipogenic events is crucial to understand the etiology and the evolution of adipogenesis-related pathologies, and to explore the adipose tissue precursors’ potential as future tools for precision medicine. |
format | Online Article Text |
id | pubmed-8858922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-88589222022-02-23 Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview Audano, M. Pedretti, S. Caruso, D. Crestani, M. De Fabiani, E. Mitro, N. Cell Mol Life Sci Review The adipose organ comprises two main fat depots termed white and brown adipose tissues. Adipogenesis is a process leading to newly differentiated adipocytes starting from precursor cells, which requires the contribution of many cellular activities at the genome, transcriptome, proteome, and metabolome levels. The adipogenic program is accomplished through two sequential phases; the first includes events favoring the commitment of adipose tissue stem cells/precursors to preadipocytes, while the second involves mechanisms that allow the achievement of full adipocyte differentiation. While there is a very large literature about the mechanisms involved in terminal adipogenesis, little is known about the first stage of this process. Growing interest in this field is due to the recent identification of adipose tissue precursors, which include a heterogenous cell population within different types of adipose tissue as well as within the same fat depot. In addition, the alteration of the heterogeneity of adipose tissue stem cells and of the mechanisms involved in their commitment have been linked to adipose tissue development defects and hence to the onset/progression of metabolic diseases, such as obesity. For this reason, the characterization of early adipogenic events is crucial to understand the etiology and the evolution of adipogenesis-related pathologies, and to explore the adipose tissue precursors’ potential as future tools for precision medicine. Springer International Publishing 2022-02-20 2022 /pmc/articles/PMC8858922/ /pubmed/35184223 http://dx.doi.org/10.1007/s00018-022-04169-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Audano, M. Pedretti, S. Caruso, D. Crestani, M. De Fabiani, E. Mitro, N. Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview |
title | Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview |
title_full | Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview |
title_fullStr | Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview |
title_full_unstemmed | Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview |
title_short | Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview |
title_sort | regulatory mechanisms of the early phase of white adipocyte differentiation: an overview |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858922/ https://www.ncbi.nlm.nih.gov/pubmed/35184223 http://dx.doi.org/10.1007/s00018-022-04169-6 |
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