Prophylactic Cranial Irradiation for Extensive-Stage Small-Cell Lung Cancer: A Controversial Area

Small-cell lung cancer (SCLC) is a highly aggressive malignant tumor that is prone to lead to the development of brain metastases (BM). The application of prophylactic cranial irradiation (PCI) has been regarded as an important technological advance made in cancer therapy to reduce the occurrence of...

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Autores principales: Xue, Shuyu, Zeng, Hanqiao, Yan, Shu, Wang, Qianmeng, Jia, Xiaojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858935/
https://www.ncbi.nlm.nih.gov/pubmed/35198438
http://dx.doi.org/10.3389/fonc.2022.772282
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author Xue, Shuyu
Zeng, Hanqiao
Yan, Shu
Wang, Qianmeng
Jia, Xiaojing
author_facet Xue, Shuyu
Zeng, Hanqiao
Yan, Shu
Wang, Qianmeng
Jia, Xiaojing
author_sort Xue, Shuyu
collection PubMed
description Small-cell lung cancer (SCLC) is a highly aggressive malignant tumor that is prone to lead to the development of brain metastases (BM). The application of prophylactic cranial irradiation (PCI) has been regarded as an important technological advance made in cancer therapy to reduce the occurrence of BM and improve patient survival. The benefits of PCI in the treatment of limited-stage SCLC have been confirmed. However, there has been continuous controversy about the indications and advantages of PCI for extensive-stage SCLC (ES-SCLC) because of the conflicting results from two prospective trials. In this review, we aimed to discuss the relevant controversy and progress made in the clinical application of PCI in ES-SCLC.
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spelling pubmed-88589352022-02-22 Prophylactic Cranial Irradiation for Extensive-Stage Small-Cell Lung Cancer: A Controversial Area Xue, Shuyu Zeng, Hanqiao Yan, Shu Wang, Qianmeng Jia, Xiaojing Front Oncol Oncology Small-cell lung cancer (SCLC) is a highly aggressive malignant tumor that is prone to lead to the development of brain metastases (BM). The application of prophylactic cranial irradiation (PCI) has been regarded as an important technological advance made in cancer therapy to reduce the occurrence of BM and improve patient survival. The benefits of PCI in the treatment of limited-stage SCLC have been confirmed. However, there has been continuous controversy about the indications and advantages of PCI for extensive-stage SCLC (ES-SCLC) because of the conflicting results from two prospective trials. In this review, we aimed to discuss the relevant controversy and progress made in the clinical application of PCI in ES-SCLC. Frontiers Media S.A. 2022-02-07 /pmc/articles/PMC8858935/ /pubmed/35198438 http://dx.doi.org/10.3389/fonc.2022.772282 Text en Copyright © 2022 Xue, Zeng, Yan, Wang and Jia https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xue, Shuyu
Zeng, Hanqiao
Yan, Shu
Wang, Qianmeng
Jia, Xiaojing
Prophylactic Cranial Irradiation for Extensive-Stage Small-Cell Lung Cancer: A Controversial Area
title Prophylactic Cranial Irradiation for Extensive-Stage Small-Cell Lung Cancer: A Controversial Area
title_full Prophylactic Cranial Irradiation for Extensive-Stage Small-Cell Lung Cancer: A Controversial Area
title_fullStr Prophylactic Cranial Irradiation for Extensive-Stage Small-Cell Lung Cancer: A Controversial Area
title_full_unstemmed Prophylactic Cranial Irradiation for Extensive-Stage Small-Cell Lung Cancer: A Controversial Area
title_short Prophylactic Cranial Irradiation for Extensive-Stage Small-Cell Lung Cancer: A Controversial Area
title_sort prophylactic cranial irradiation for extensive-stage small-cell lung cancer: a controversial area
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858935/
https://www.ncbi.nlm.nih.gov/pubmed/35198438
http://dx.doi.org/10.3389/fonc.2022.772282
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