The Styryl Benzoic Acid Derivative DC10 Potentiates Radiotherapy by Targeting the xCT-Glutathione Axis

Metastatic tumors with moderate radiosensitivity account for most cancer-related deaths, highlighting the limitations of current radiotherapy regimens. The xCT-inhibitor sulfasalazine (SAS) sensitizes cancer cells to radiotherapy by blocking cystine uptake via the xCT membrane antiporter, and thereb...

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Detalles Bibliográficos
Autores principales: Sarowar, Shahin, Cirillo, Davide, Játiva, Pablo, Nilsen, Mette Hartmark, Otragane, Sarah-Muheha Anni, Heggdal, Jan, Selheim, Frode, Ceña, Valentín, Bjørsvik, Hans-René, Enger, Per Øyvind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858948/
https://www.ncbi.nlm.nih.gov/pubmed/35198439
http://dx.doi.org/10.3389/fonc.2022.786739

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