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Th17 CD4+ T-Cell as a Preferential Target for HIV Reservoirs
Among CD4+ T-cells, T helper 17 (Th17) cells play a sentinel role in the defense against bacterial/fungal pathogens at mucosal barriers. However, Th17 cells are also highly susceptible to HIV-1 infection and are rapidly depleted from gut mucosal sites, causing an imbalance of the Th17/Treg ratio and...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858966/ https://www.ncbi.nlm.nih.gov/pubmed/35197986 http://dx.doi.org/10.3389/fimmu.2022.822576 |
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author | Renault, Constance Veyrenche, Nicolas Mennechet, Franck Bedin, Anne-Sophie Routy, Jean-Pierre Van de Perre, Philippe Reynes, Jacques Tuaillon, Edouard |
author_facet | Renault, Constance Veyrenche, Nicolas Mennechet, Franck Bedin, Anne-Sophie Routy, Jean-Pierre Van de Perre, Philippe Reynes, Jacques Tuaillon, Edouard |
author_sort | Renault, Constance |
collection | PubMed |
description | Among CD4+ T-cells, T helper 17 (Th17) cells play a sentinel role in the defense against bacterial/fungal pathogens at mucosal barriers. However, Th17 cells are also highly susceptible to HIV-1 infection and are rapidly depleted from gut mucosal sites, causing an imbalance of the Th17/Treg ratio and impairing cytokines production. Consequently, damage to the gut mucosal barrier leads to an enhanced microbial translocation and systemic inflammation, a hallmark of HIV-1 disease progression. Th17 cells’ expression of mucosal homing receptors (CCR6 and α4β7), as well as HIV receptors and co-receptors (CD4, α4β7, CCR5, and CXCR4), contributes to susceptibility to HIV infection. The up-regulation of numerous intracellular factors facilitating HIV production, alongside the downregulation of factors inhibiting HIV, helps to explain the frequency of HIV DNA within Th17 cells. Th17 cells harbor long-lived viral reservoirs in people living with HIV (PLWH) receiving antiretroviral therapy (ART). Moreover, cell longevity and the proliferation of a fraction of Th17 CD4 T cells allow HIV reservoirs to be maintained in ART patients. |
format | Online Article Text |
id | pubmed-8858966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88589662022-02-22 Th17 CD4+ T-Cell as a Preferential Target for HIV Reservoirs Renault, Constance Veyrenche, Nicolas Mennechet, Franck Bedin, Anne-Sophie Routy, Jean-Pierre Van de Perre, Philippe Reynes, Jacques Tuaillon, Edouard Front Immunol Immunology Among CD4+ T-cells, T helper 17 (Th17) cells play a sentinel role in the defense against bacterial/fungal pathogens at mucosal barriers. However, Th17 cells are also highly susceptible to HIV-1 infection and are rapidly depleted from gut mucosal sites, causing an imbalance of the Th17/Treg ratio and impairing cytokines production. Consequently, damage to the gut mucosal barrier leads to an enhanced microbial translocation and systemic inflammation, a hallmark of HIV-1 disease progression. Th17 cells’ expression of mucosal homing receptors (CCR6 and α4β7), as well as HIV receptors and co-receptors (CD4, α4β7, CCR5, and CXCR4), contributes to susceptibility to HIV infection. The up-regulation of numerous intracellular factors facilitating HIV production, alongside the downregulation of factors inhibiting HIV, helps to explain the frequency of HIV DNA within Th17 cells. Th17 cells harbor long-lived viral reservoirs in people living with HIV (PLWH) receiving antiretroviral therapy (ART). Moreover, cell longevity and the proliferation of a fraction of Th17 CD4 T cells allow HIV reservoirs to be maintained in ART patients. Frontiers Media S.A. 2022-02-07 /pmc/articles/PMC8858966/ /pubmed/35197986 http://dx.doi.org/10.3389/fimmu.2022.822576 Text en Copyright © 2022 Renault, Veyrenche, Mennechet, Bedin, Routy, Van de Perre, Reynes and Tuaillon https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Renault, Constance Veyrenche, Nicolas Mennechet, Franck Bedin, Anne-Sophie Routy, Jean-Pierre Van de Perre, Philippe Reynes, Jacques Tuaillon, Edouard Th17 CD4+ T-Cell as a Preferential Target for HIV Reservoirs |
title | Th17 CD4+ T-Cell as a Preferential Target for HIV Reservoirs |
title_full | Th17 CD4+ T-Cell as a Preferential Target for HIV Reservoirs |
title_fullStr | Th17 CD4+ T-Cell as a Preferential Target for HIV Reservoirs |
title_full_unstemmed | Th17 CD4+ T-Cell as a Preferential Target for HIV Reservoirs |
title_short | Th17 CD4+ T-Cell as a Preferential Target for HIV Reservoirs |
title_sort | th17 cd4+ t-cell as a preferential target for hiv reservoirs |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858966/ https://www.ncbi.nlm.nih.gov/pubmed/35197986 http://dx.doi.org/10.3389/fimmu.2022.822576 |
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