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A188 FACTORS ASSOCIATED WITH CLINICAL REMISSION IN PEDIATRIC LUMINAL CROHN’S DISEASE: A RETROSPECTIVE COHORT STUDY

BACKGROUND: The natural evolution of Crohn’s disease is incompletely understood in the pediatric population. Data on factors influencing time-to-remission are very limited in the literature. AIMS: The aim of this retrospective cohort study was to describe the time to clinical remission in children w...

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Autores principales: Sassine, S, Fadela Zekhnine, S, Qaddouri, M, Djani, L, Cambron-Asselin, C, Savoie-Robichaud, M, Lin, Y, Grzywacz, K, Groleau, V, Dirks, M, Drouin, É, Halac, U, Marchand, V, Girard, C, Courbette, O, Patey, N, Dal Soglio, D, Deslandres, C, Jantchou, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859212/
http://dx.doi.org/10.1093/jcag/gwab049.187
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author Sassine, S
Fadela Zekhnine, S
Qaddouri, M
Djani, L
Cambron-Asselin, C
Savoie-Robichaud, M
Lin, Y
Grzywacz, K
Groleau, V
Dirks, M
Drouin, É
Halac, U
Marchand, V
Girard, C
Courbette, O
Patey, N
Dal Soglio, D
Deslandres, C
Jantchou, P
author_facet Sassine, S
Fadela Zekhnine, S
Qaddouri, M
Djani, L
Cambron-Asselin, C
Savoie-Robichaud, M
Lin, Y
Grzywacz, K
Groleau, V
Dirks, M
Drouin, É
Halac, U
Marchand, V
Girard, C
Courbette, O
Patey, N
Dal Soglio, D
Deslandres, C
Jantchou, P
author_sort Sassine, S
collection PubMed
description BACKGROUND: The natural evolution of Crohn’s disease is incompletely understood in the pediatric population. Data on factors influencing time-to-remission are very limited in the literature. AIMS: The aim of this retrospective cohort study was to describe the time to clinical remission in children with Crohn’s disease as well as changes over the past decade and to identify factors associated with time to clinical remission. METHODS: Patients under 18 years old diagnosed between 2009 and 2019 were included. All data were collected from the patients’ medical records and the CHU Sainte-Justine inflammatory bowel disease registry. Survival analyses and linear regression models were used to assess the impact of clinical, laboratory, endoscopic, histological and therapeutic factors on time to clinical remission. RESULTS: 654 patients were included in the study. There was no change in the time to clinical remission over the past decade. Female sex in adolescents (ajusted bêta regression coefficient (aβ)= 31.8 days, p= 0.02), upper digestive tract involvement (aβ= 46.4 days, p= 0.04), perianal disease (aβ= 32.2 days, p= 0.04), presence of active inflammation on biopsies (aβ= 46.7 days, p= 0.01) and oral 5-ASA exposure (aβ=56.6 days, p= 0.002) were all associated with longer time to clinical remission. However, antibiotic exposure (aβ= -29.3 days, p=0.04), increased eosinophils on biopsies (aβ= -29.6 days, p=0.008) and combination of exclusive enteral nutrition and TNF- alpha inhibitors as induction therapy (aβ= -36.8, p=0.04) were associated with shorter time to clinical remission. CONCLUSIONS: Time to clinical remission did not improve during the decade and was associated with baseline clinical and histological data and treatment strategies. Combination of enteral nutrition and TNF-alpha inhibitors was associated with faster clinical remission. [Image: see text] Kaplan-Meier curve representing the time to clinical remission of patients according to the first induction treatment administered. FUNDING AGENCIES: NoneFonds Recherche Santé Québec / Fondation du CHU Sainte-Justine
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spelling pubmed-88592122022-02-22 A188 FACTORS ASSOCIATED WITH CLINICAL REMISSION IN PEDIATRIC LUMINAL CROHN’S DISEASE: A RETROSPECTIVE COHORT STUDY Sassine, S Fadela Zekhnine, S Qaddouri, M Djani, L Cambron-Asselin, C Savoie-Robichaud, M Lin, Y Grzywacz, K Groleau, V Dirks, M Drouin, É Halac, U Marchand, V Girard, C Courbette, O Patey, N Dal Soglio, D Deslandres, C Jantchou, P J Can Assoc Gastroenterol Poster of Distinction BACKGROUND: The natural evolution of Crohn’s disease is incompletely understood in the pediatric population. Data on factors influencing time-to-remission are very limited in the literature. AIMS: The aim of this retrospective cohort study was to describe the time to clinical remission in children with Crohn’s disease as well as changes over the past decade and to identify factors associated with time to clinical remission. METHODS: Patients under 18 years old diagnosed between 2009 and 2019 were included. All data were collected from the patients’ medical records and the CHU Sainte-Justine inflammatory bowel disease registry. Survival analyses and linear regression models were used to assess the impact of clinical, laboratory, endoscopic, histological and therapeutic factors on time to clinical remission. RESULTS: 654 patients were included in the study. There was no change in the time to clinical remission over the past decade. Female sex in adolescents (ajusted bêta regression coefficient (aβ)= 31.8 days, p= 0.02), upper digestive tract involvement (aβ= 46.4 days, p= 0.04), perianal disease (aβ= 32.2 days, p= 0.04), presence of active inflammation on biopsies (aβ= 46.7 days, p= 0.01) and oral 5-ASA exposure (aβ=56.6 days, p= 0.002) were all associated with longer time to clinical remission. However, antibiotic exposure (aβ= -29.3 days, p=0.04), increased eosinophils on biopsies (aβ= -29.6 days, p=0.008) and combination of exclusive enteral nutrition and TNF- alpha inhibitors as induction therapy (aβ= -36.8, p=0.04) were associated with shorter time to clinical remission. CONCLUSIONS: Time to clinical remission did not improve during the decade and was associated with baseline clinical and histological data and treatment strategies. Combination of enteral nutrition and TNF-alpha inhibitors was associated with faster clinical remission. [Image: see text] Kaplan-Meier curve representing the time to clinical remission of patients according to the first induction treatment administered. FUNDING AGENCIES: NoneFonds Recherche Santé Québec / Fondation du CHU Sainte-Justine Oxford University Press 2022-02-21 /pmc/articles/PMC8859212/ http://dx.doi.org/10.1093/jcag/gwab049.187 Text en ڣ The Author(s) 2022. Published by Oxford University Press on behalf of the Canadian Association of Gastroenterology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Poster of Distinction
Sassine, S
Fadela Zekhnine, S
Qaddouri, M
Djani, L
Cambron-Asselin, C
Savoie-Robichaud, M
Lin, Y
Grzywacz, K
Groleau, V
Dirks, M
Drouin, É
Halac, U
Marchand, V
Girard, C
Courbette, O
Patey, N
Dal Soglio, D
Deslandres, C
Jantchou, P
A188 FACTORS ASSOCIATED WITH CLINICAL REMISSION IN PEDIATRIC LUMINAL CROHN’S DISEASE: A RETROSPECTIVE COHORT STUDY
title A188 FACTORS ASSOCIATED WITH CLINICAL REMISSION IN PEDIATRIC LUMINAL CROHN’S DISEASE: A RETROSPECTIVE COHORT STUDY
title_full A188 FACTORS ASSOCIATED WITH CLINICAL REMISSION IN PEDIATRIC LUMINAL CROHN’S DISEASE: A RETROSPECTIVE COHORT STUDY
title_fullStr A188 FACTORS ASSOCIATED WITH CLINICAL REMISSION IN PEDIATRIC LUMINAL CROHN’S DISEASE: A RETROSPECTIVE COHORT STUDY
title_full_unstemmed A188 FACTORS ASSOCIATED WITH CLINICAL REMISSION IN PEDIATRIC LUMINAL CROHN’S DISEASE: A RETROSPECTIVE COHORT STUDY
title_short A188 FACTORS ASSOCIATED WITH CLINICAL REMISSION IN PEDIATRIC LUMINAL CROHN’S DISEASE: A RETROSPECTIVE COHORT STUDY
title_sort a188 factors associated with clinical remission in pediatric luminal crohn’s disease: a retrospective cohort study
topic Poster of Distinction
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859212/
http://dx.doi.org/10.1093/jcag/gwab049.187
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