Cargando…

Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond

Patients with heart failure often develop cardiac arrhythmias. The mechanisms and interrelations linking heart failure and arrhythmias are not fully understood. Historically, research into arrhythmias has been performed on affected individuals or in vivo (animal) models. The latter however is constr...

Descripción completa

Detalles Bibliográficos
Autores principales: Cumberland, Max J., Riebel, Leto L., Roy, Ashwin, O’Shea, Christopher, Holmes, Andrew P., Denning, Chris, Kirchhof, Paulus, Rodriguez, Blanca, Gehmlich, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859441/
https://www.ncbi.nlm.nih.gov/pubmed/35197863
http://dx.doi.org/10.3389/fphys.2022.806366
_version_ 1784654462748459008
author Cumberland, Max J.
Riebel, Leto L.
Roy, Ashwin
O’Shea, Christopher
Holmes, Andrew P.
Denning, Chris
Kirchhof, Paulus
Rodriguez, Blanca
Gehmlich, Katja
author_facet Cumberland, Max J.
Riebel, Leto L.
Roy, Ashwin
O’Shea, Christopher
Holmes, Andrew P.
Denning, Chris
Kirchhof, Paulus
Rodriguez, Blanca
Gehmlich, Katja
author_sort Cumberland, Max J.
collection PubMed
description Patients with heart failure often develop cardiac arrhythmias. The mechanisms and interrelations linking heart failure and arrhythmias are not fully understood. Historically, research into arrhythmias has been performed on affected individuals or in vivo (animal) models. The latter however is constrained by interspecies variation, demands to reduce animal experiments and cost. Recent developments in in vitro induced pluripotent stem cell technology and in silico modelling have expanded the number of models available for the evaluation of heart failure and arrhythmia. An agnostic approach, combining the modalities discussed here, has the potential to improve our understanding for appraising the pathology and interactions between heart failure and arrhythmia and can provide robust and validated outcomes in a variety of research settings. This review discusses the state of the art models, methodologies and techniques used in the evaluation of heart failure and arrhythmia and will highlight the benefits of using them in combination. Special consideration is paid to assessing the pivotal role calcium handling has in the development of heart failure and arrhythmia.
format Online
Article
Text
id pubmed-8859441
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-88594412022-02-22 Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond Cumberland, Max J. Riebel, Leto L. Roy, Ashwin O’Shea, Christopher Holmes, Andrew P. Denning, Chris Kirchhof, Paulus Rodriguez, Blanca Gehmlich, Katja Front Physiol Physiology Patients with heart failure often develop cardiac arrhythmias. The mechanisms and interrelations linking heart failure and arrhythmias are not fully understood. Historically, research into arrhythmias has been performed on affected individuals or in vivo (animal) models. The latter however is constrained by interspecies variation, demands to reduce animal experiments and cost. Recent developments in in vitro induced pluripotent stem cell technology and in silico modelling have expanded the number of models available for the evaluation of heart failure and arrhythmia. An agnostic approach, combining the modalities discussed here, has the potential to improve our understanding for appraising the pathology and interactions between heart failure and arrhythmia and can provide robust and validated outcomes in a variety of research settings. This review discusses the state of the art models, methodologies and techniques used in the evaluation of heart failure and arrhythmia and will highlight the benefits of using them in combination. Special consideration is paid to assessing the pivotal role calcium handling has in the development of heart failure and arrhythmia. Frontiers Media S.A. 2022-02-07 /pmc/articles/PMC8859441/ /pubmed/35197863 http://dx.doi.org/10.3389/fphys.2022.806366 Text en Copyright © 2022 Cumberland, Riebel, Roy, O’Shea, Holmes, Denning, Kirchhof, Rodriguez and Gehmlich. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Cumberland, Max J.
Riebel, Leto L.
Roy, Ashwin
O’Shea, Christopher
Holmes, Andrew P.
Denning, Chris
Kirchhof, Paulus
Rodriguez, Blanca
Gehmlich, Katja
Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond
title Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond
title_full Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond
title_fullStr Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond
title_full_unstemmed Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond
title_short Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond
title_sort basic research approaches to evaluate cardiac arrhythmia in heart failure and beyond
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859441/
https://www.ncbi.nlm.nih.gov/pubmed/35197863
http://dx.doi.org/10.3389/fphys.2022.806366
work_keys_str_mv AT cumberlandmaxj basicresearchapproachestoevaluatecardiacarrhythmiainheartfailureandbeyond
AT riebelletol basicresearchapproachestoevaluatecardiacarrhythmiainheartfailureandbeyond
AT royashwin basicresearchapproachestoevaluatecardiacarrhythmiainheartfailureandbeyond
AT osheachristopher basicresearchapproachestoevaluatecardiacarrhythmiainheartfailureandbeyond
AT holmesandrewp basicresearchapproachestoevaluatecardiacarrhythmiainheartfailureandbeyond
AT denningchris basicresearchapproachestoevaluatecardiacarrhythmiainheartfailureandbeyond
AT kirchhofpaulus basicresearchapproachestoevaluatecardiacarrhythmiainheartfailureandbeyond
AT rodriguezblanca basicresearchapproachestoevaluatecardiacarrhythmiainheartfailureandbeyond
AT gehmlichkatja basicresearchapproachestoevaluatecardiacarrhythmiainheartfailureandbeyond