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Metformin maintains intrahepatic triglyceride content through increased hepatic de novo lipogenesis

OBJECTIVE: Metformin is a first-line pharmacotherapy in the treatment of type 2 diabetes, a condition closely associated with non-alcoholic fatty liver disease (NAFLD). Although metformin promotes weight loss and improves insulin sensitivity, its effect on intrahepatic triglyceride (IHTG) remains un...

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Detalles Bibliográficos
Autores principales: Green, Charlotte J, Marjot, Thomas, Walsby-Tickle, John, Charlton, Catriona, Cornfield, Thomas, Westcott, Felix, Pinnick, Katherine E, Moolla, Ahmad, Hazlehurst, Jonathan M, McCullagh, James, Tomlinson, Jeremy W, Hodson, Leanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859923/
https://www.ncbi.nlm.nih.gov/pubmed/35038311
http://dx.doi.org/10.1530/EJE-21-0850