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Individual and joint effects of trehalose and glutamate on diabetic retinopathy: a propensity score-matched case–control study

Although previous studies demonstrate that trehalose can help maintain glucose homeostasis in healthy humans, its role and joint effect with glutamate on diabetic retinopathy (DR) remain unclear. We aimed to comprehensively quantify the associations of trehalose and glutamate with DR. This study inc...

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Autores principales: Guo, Chengnan, Xu, Yixi, Ma, Yange, Xu, Xin, Peng, Fang, Li, Hui-hui, Jin, Dongzhen, Zhao, Shu-zhen, Xia, Zhezheng, Lai, Mengyuan, Che, Mingzhu, Huang, Ruogu, Wang, Yanan, Jiang, Depeng, Zheng, Chao, Mao, Guangyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859951/
https://www.ncbi.nlm.nih.gov/pubmed/35029545
http://dx.doi.org/10.1530/EC-21-0474
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author Guo, Chengnan
Xu, Yixi
Ma, Yange
Xu, Xin
Peng, Fang
Li, Hui-hui
Jin, Dongzhen
Zhao, Shu-zhen
Xia, Zhezheng
Lai, Mengyuan
Che, Mingzhu
Huang, Ruogu
Wang, Yanan
Jiang, Depeng
Zheng, Chao
Mao, Guangyun
author_facet Guo, Chengnan
Xu, Yixi
Ma, Yange
Xu, Xin
Peng, Fang
Li, Hui-hui
Jin, Dongzhen
Zhao, Shu-zhen
Xia, Zhezheng
Lai, Mengyuan
Che, Mingzhu
Huang, Ruogu
Wang, Yanan
Jiang, Depeng
Zheng, Chao
Mao, Guangyun
author_sort Guo, Chengnan
collection PubMed
description Although previous studies demonstrate that trehalose can help maintain glucose homeostasis in healthy humans, its role and joint effect with glutamate on diabetic retinopathy (DR) remain unclear. We aimed to comprehensively quantify the associations of trehalose and glutamate with DR. This study included 69 pairs of DR and matched type 2 diabetic (T2D) patients. Serum trehalose and glutamate were determined via ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry system. Covariates were collected by a standardized questionnaire, clinical examinations and laboratory assessments. Individual and joint association of trehalose and glutamate with DR were quantified by multiple conditional logistic regression models. The adjusted odds of DR averagely decreased by 86% (odds ratio (OR): 0.14; 95% CI: 0.06, 0.33) with per interquartile range increase of trehalose. Comparing with the lowest quartile, adjusted OR (95% CI) were 0.20 (0.05, 0.83), 0.14 (0.03, 0.63) and 0.01 (<0.01, 0.05) for participants in the second, third and fourth quartiles of trehalose, respectively. In addition, as compared to their counterparts, T2D patients with lower trehalose (<median) and higher glutamate (≥median) had the highest odds of DR (OR: 36.81; 95% CI: 6.75, 200.61). An apparent super-multiplicative effect of trehalose and glutamate on DR was observed, whereas relative excess risk due to interaction was not significant. The study suggests that trehalose is beneficial to inhibit the occurrence of DR and synergistically decreases the risk of DR with reduced glutamate. Our findings also provide new insights into the mechanisms of DR and further longitudinal studies are required to confirm these findings.
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spelling pubmed-88599512022-02-23 Individual and joint effects of trehalose and glutamate on diabetic retinopathy: a propensity score-matched case–control study Guo, Chengnan Xu, Yixi Ma, Yange Xu, Xin Peng, Fang Li, Hui-hui Jin, Dongzhen Zhao, Shu-zhen Xia, Zhezheng Lai, Mengyuan Che, Mingzhu Huang, Ruogu Wang, Yanan Jiang, Depeng Zheng, Chao Mao, Guangyun Endocr Connect Research Although previous studies demonstrate that trehalose can help maintain glucose homeostasis in healthy humans, its role and joint effect with glutamate on diabetic retinopathy (DR) remain unclear. We aimed to comprehensively quantify the associations of trehalose and glutamate with DR. This study included 69 pairs of DR and matched type 2 diabetic (T2D) patients. Serum trehalose and glutamate were determined via ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry system. Covariates were collected by a standardized questionnaire, clinical examinations and laboratory assessments. Individual and joint association of trehalose and glutamate with DR were quantified by multiple conditional logistic regression models. The adjusted odds of DR averagely decreased by 86% (odds ratio (OR): 0.14; 95% CI: 0.06, 0.33) with per interquartile range increase of trehalose. Comparing with the lowest quartile, adjusted OR (95% CI) were 0.20 (0.05, 0.83), 0.14 (0.03, 0.63) and 0.01 (<0.01, 0.05) for participants in the second, third and fourth quartiles of trehalose, respectively. In addition, as compared to their counterparts, T2D patients with lower trehalose (<median) and higher glutamate (≥median) had the highest odds of DR (OR: 36.81; 95% CI: 6.75, 200.61). An apparent super-multiplicative effect of trehalose and glutamate on DR was observed, whereas relative excess risk due to interaction was not significant. The study suggests that trehalose is beneficial to inhibit the occurrence of DR and synergistically decreases the risk of DR with reduced glutamate. Our findings also provide new insights into the mechanisms of DR and further longitudinal studies are required to confirm these findings. Bioscientifica Ltd 2022-01-14 /pmc/articles/PMC8859951/ /pubmed/35029545 http://dx.doi.org/10.1530/EC-21-0474 Text en © The authors https://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Research
Guo, Chengnan
Xu, Yixi
Ma, Yange
Xu, Xin
Peng, Fang
Li, Hui-hui
Jin, Dongzhen
Zhao, Shu-zhen
Xia, Zhezheng
Lai, Mengyuan
Che, Mingzhu
Huang, Ruogu
Wang, Yanan
Jiang, Depeng
Zheng, Chao
Mao, Guangyun
Individual and joint effects of trehalose and glutamate on diabetic retinopathy: a propensity score-matched case–control study
title Individual and joint effects of trehalose and glutamate on diabetic retinopathy: a propensity score-matched case–control study
title_full Individual and joint effects of trehalose and glutamate on diabetic retinopathy: a propensity score-matched case–control study
title_fullStr Individual and joint effects of trehalose and glutamate on diabetic retinopathy: a propensity score-matched case–control study
title_full_unstemmed Individual and joint effects of trehalose and glutamate on diabetic retinopathy: a propensity score-matched case–control study
title_short Individual and joint effects of trehalose and glutamate on diabetic retinopathy: a propensity score-matched case–control study
title_sort individual and joint effects of trehalose and glutamate on diabetic retinopathy: a propensity score-matched case–control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859951/
https://www.ncbi.nlm.nih.gov/pubmed/35029545
http://dx.doi.org/10.1530/EC-21-0474
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