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Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism
Hypothyroidism is often associated with elevated serum levels of total cholesterol, LDL-C and triglycerides. Thyroid hormone (TH) affects the production, clearance and transformation of cholesterol, but current research shows that thyroid-stimulating hormone (TSH) also participates in lipid metaboli...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bioscientifica Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859969/ https://www.ncbi.nlm.nih.gov/pubmed/35015703 http://dx.doi.org/10.1530/EC-21-0002 |
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author | Liu, Huixing Peng, Daoquan |
author_facet | Liu, Huixing Peng, Daoquan |
author_sort | Liu, Huixing |
collection | PubMed |
description | Hypothyroidism is often associated with elevated serum levels of total cholesterol, LDL-C and triglycerides. Thyroid hormone (TH) affects the production, clearance and transformation of cholesterol, but current research shows that thyroid-stimulating hormone (TSH) also participates in lipid metabolism independently of TH. Therefore, the mechanism of hypothyroidism-related dyslipidemia is associated with the decrease of TH and the increase of TSH levels. Some newly identified regulatory factors, such as proprotein convertase subtilisin/kexin type 9, angiogenin-like proteins and fibroblast growth factors are the underlying causes of dyslipidemia in hypothyroidism. HDL serum concentration changes were not consistent, and its function was reportedly impaired. The current review focuses on the updated understanding of the mechanism of hypothyroidism-related dyslipidemia. |
format | Online Article Text |
id | pubmed-8859969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-88599692022-02-23 Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism Liu, Huixing Peng, Daoquan Endocr Connect Review Hypothyroidism is often associated with elevated serum levels of total cholesterol, LDL-C and triglycerides. Thyroid hormone (TH) affects the production, clearance and transformation of cholesterol, but current research shows that thyroid-stimulating hormone (TSH) also participates in lipid metabolism independently of TH. Therefore, the mechanism of hypothyroidism-related dyslipidemia is associated with the decrease of TH and the increase of TSH levels. Some newly identified regulatory factors, such as proprotein convertase subtilisin/kexin type 9, angiogenin-like proteins and fibroblast growth factors are the underlying causes of dyslipidemia in hypothyroidism. HDL serum concentration changes were not consistent, and its function was reportedly impaired. The current review focuses on the updated understanding of the mechanism of hypothyroidism-related dyslipidemia. Bioscientifica Ltd 2022-01-11 /pmc/articles/PMC8859969/ /pubmed/35015703 http://dx.doi.org/10.1530/EC-21-0002 Text en © The authors https://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Review Liu, Huixing Peng, Daoquan Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism |
title | Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism |
title_full | Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism |
title_fullStr | Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism |
title_full_unstemmed | Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism |
title_short | Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism |
title_sort | update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859969/ https://www.ncbi.nlm.nih.gov/pubmed/35015703 http://dx.doi.org/10.1530/EC-21-0002 |
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