Cargando…

Identification of a novel subset of alveolar type 2 cells enriched in PD-L1 and expanded following pneumonectomy

Alveolar type 2 (AT2) cells are heterogeneous cells, with specialised AT2 subpopulations within this lineage exhibiting stem cell properties. However, the existence of quiescent, immature cells within the AT2 lineage that are activated during lung regeneration is unknown. Sftpc(CreERT2/+);tdTomato(f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahmadvand, Negah, Khosravi, Farhad, Lingampally, Arun, Wasnick, Roxana, Vazquez-Armendariz, Ana Ivonne, Carraro, Gianni, Heiner, Monika, Rivetti, Stefano, Lv, Yuqing, Wilhelm, Jochen, Gunther, Andreas, Herold, Susanne, Al Alam, Denise, Chen, Chengshui, Minoo, Parviz, Zhang, Jin-San, Bellusci, Saverio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Respiratory Society 2021
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859978/ https://www.ncbi.nlm.nih.gov/pubmed/33863742 http://dx.doi.org/10.1183/13993003.04168-2020

Ejemplares similares

Fgfr2b signaling is essential for the maintenance of the alveolar epithelial type 2 lineage during lung homeostasis in mice
por: Ahmadvand, Negah, et al.
Publicado: (2022)

Cell-Surface Programmed Death Ligand-1 Expression Identifies a Sub-Population of Distal Epithelial Cells Enriched in Idiopathic Pulmonary Fibrosis
por: Ahmadvand, Negah, et al.
Publicado: (2022)

Evidence for Overlapping and Distinct Biological Activities and Transcriptional Targets Triggered by Fibroblast Growth Factor Receptor 2b Signaling between Mid- and Early Pseudoglandular Stages of Mouse Lung Development
por: Jones, Matthew R., et al.
Publicado: (2020)

The Multifunctional Contribution of FGF Signaling to Cardiac Development, Homeostasis, Disease and Repair
por: Khosravi, Farhad, et al.
Publicado: (2021)

FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells
por: Jones, Matthew R., et al.
Publicado: (2022)

Injury activated alveolar progenitors (IAAPs): the underdog of lung repair
por: Chong, Lei, et al.
Publicado: (2023)

Use of the Reversible Myogenic to Lipogenic Transdifferentiation Switch for the Design of Pre-clinical Drug Screening in Idiopathic Pulmonary Fibrosis
por: Lingampally, Arun, et al.
Publicado: (2020)

A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis
por: Jones, Matthew R., et al.
Publicado: (2019)

Fgf10/Fgfr2b Signaling in Mammary Gland Development, Homeostasis, and Cancer
por: Rivetti, Stefano, et al.
Publicado: (2020)

Validation of a Novel Fgf10(Cre–ERT2) Knock-in Mouse Line Targeting FGF10(Pos) Cells Postnatally
por: Chu, Xuran, et al.
Publicado: (2021)

Induction of Stem-Cell-Derived Cardiomyogenesis by Fibroblast Growth Factor 10 (FGF10) and Its Interplay with Cardiotrophin-1 (CT-1)
por: Khosravi, Farhad, et al.
Publicado: (2022)

Insights into the Black Box of Intra-Amniotic Infection and Its Impact on the Premature Lung: From Clinical and Preclinical Perspectives
por: Dong, Ying, et al.
Publicado: (2022)

FGF10 Triggers De Novo Alveologenesis in a Bronchopulmonary Dysplasia Model: Impact on Resident Mesenchymal Niche Cells
por: Taghizadeh, Sara, et al.
Publicado: (2022)

Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
por: Kheirollahi, Vahid, et al.
Publicado: (2019)

Evidence for Multiple Origins of De Novo Formed Vascular Smooth Muscle Cells in Pulmonary Hypertension: Challenging the Dominant Model of Pre-Existing Smooth Muscle Expansion
por: Chu, Xuran, et al.
Publicado: (2021)

Characterization of Tg(Etv4-GFP) and Etv5(RFP) Reporter Lines in the Context of Fibroblast Growth Factor 10 Signaling During Mouse Embryonic Lung Development
por: Jones, Matthew R., et al.
Publicado: (2019)

Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by β-catenin Signaling
por: De Langhe, Stijn P., et al.
Publicado: (2008)

Cross-Talk Between Inflammation and Fibroblast Growth Factor 10 During Organogenesis and Pathogenesis: Lessons Learnt From the Lung and Other Organs
por: Marega, Manuela, et al.
Publicado: (2021)

A Breath of Fresh Air on the Mesenchyme: Impact of Impaired Mesenchymal Development on the Pathogenesis of Bronchopulmonary Dysplasia
por: Chao, Cho-Ming, et al.
Publicado: (2015)

Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration
por: Moiseenko, Alena, et al.
Publicado: (2020)

FGF10 Therapeutic Administration Promotes Mobilization of Injury-Activated Alveolar Progenitors in a Mouse Fibrosis Model
por: Lv, Yu-Qing, et al.
Publicado: (2022)

Failure to Down-Regulate miR-154 Expression in Early Postnatal Mouse Lung Epithelium Suppresses Alveologenesis, with Changes in Tgf-β Signaling Similar to those Induced by Exposure to Hyperoxia
por: Chao, Cho-Ming, et al.
Publicado: (2020)

Role of Fibroblast Growth Factor 10 in Mesenchymal Cell Differentiation During Lung Development and Disease
por: Wu, Jin, et al.
Publicado: (2018)

Primary pneumonectomy, pneumonectomy after induction therapy, and salvage pneumonectomy: a comparison of surgical and prognostic outcomes
por: Sakakura, Noriaki, et al.
Publicado: (2020)

Multilineage murine stem cells generate complex organoids to model distal lung development and disease
por: Vazquez‐Armendariz, Ana Ivonne, et al.
Publicado: (2020)

Differential LysoTracker Uptake Defines Two Populations of Distal Epithelial Cells in Idiopathic Pulmonary Fibrosis
por: Wasnick, Roxana Maria, et al.
Publicado: (2022)

SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains
por: Minoo, Parviz, et al.
Publicado: (2008)

From Clones to Buds and Branches: The Use of Lung Organoids to Model Branching Morphogenesis Ex Vivo
por: Vazquez-Armendariz, Ana Ivonne, et al.
Publicado: (2021)

Thoracoscopic Assisted Pneumonectomy
por: Podbielski, Francis J., et al.
Publicado: (1997)

UK pneumonectomy outcome study (UKPOS): a prospective observational study of pneumonectomy outcome
por: Powell, Ellie S, et al.
Publicado: (2009)

VATS Pneumonectomy: The Posterior Approach
por: Miller, D, et al.
Publicado: (2015)

Tension chylothorax following pneumonectomy
por: Yadav, Hemang, et al.
Publicado: (2014)

Lobectomy and Pneumonectomy for Pulmonary Tuberculosis
por: Janes, R. M.
Publicado: (1950)

Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast growth factors
por: Chu, Xuran, et al.
Publicado: (2019)

Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis
por: MacKenzie, BreAnne, et al.
Publicado: (2015)

Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate
por: Li, Aimin, et al.
Publicado: (2016)

GLI1+ cells are a source of repair-supportive mesenchymal cells (RSMCs) during airway epithelial regeneration
por: Chu, Xuran, et al.
Publicado: (2022)

FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes
por: Lv, Yu-Qing, et al.
Publicado: (2021)

Cardiac surgery in patients with previous pneumonectomy
por: Ghotkar, Sanjay V, et al.
Publicado: (2008)

Left diaphragmatic hernia after pneumonectomy
por: Piraccini, E, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_uovt5rptru8kkfpiuf4k0k1ate