Efficacy of probucol on cognitive function in Alzheimer’s disease: study protocol for a double-blind, placebo-controlled, randomised phase II trial (PIA study)

INTRODUCTION: Preclinical, clinical and epidemiological studies support the hypothesis that aberrant systemic metabolism of amyloid beta (Aβ) in the peripheral circulation is causally related to the development of Alzheimer’s disease (AD). Specifically, recent studies suggest that increased plasma c...

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Detalles Bibliográficos
Autores principales: Lam, Virginie, Clarnette, Roger, Francis, Roslyn, Bynevelt, Michael, Watts, Gerald, Flicker, Leon, Orr, Carolyn F, Loh, Poh, Lautenschlager, Nicola, Reid, Christopher M, Foster, Jonathan K, Dhaliwal, Satvinder S, Robinson, Suzanne, Corti, Emily, Vaccarezza, Mauro, Horgan, Ben, Takechi, Ryusuke, Mamo, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860076/
https://www.ncbi.nlm.nih.gov/pubmed/35190446
http://dx.doi.org/10.1136/bmjopen-2021-058826

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